Eating patterns and risk of colon cancer
Eating patterns and risk of colon cancer
复制标题
DOI：
10.1093/aje/148.1.4-a
复制
发表时间：
1998-07-01
影响因子：
5
通讯作者：
Ma, KN
中科院分区：
文献类型：
--
作者：
Slattery, ML;Boucher, KM;Ma, KN
结肠癌与几种营养素和食物有关。作者使用了在北方加州、犹他州和明尼苏达州进行的基于人群的研究数据，以检查饮食模式与患结肠癌风险之间的关系。通过因子分析，从1991-1994年诊断的1,993例病例和2,410例对照中获得的详细饮食摄入数据被分组为因子，以评估与生活方式特征和结肠癌风险的关系。出现了几种饮食模式。最具变化的饮食模式被标记为“西方”、“谨慎”、“高脂肪/糖乳制品”、“替代品”和“饮酒者”。“西方”饮食模式与较高的身体质量指数和较高的总能量和膳食胆固醇摄入量有关。“谨慎”的模式与更高水平的激烈的休闲时间体育活动，较小的体型，以及更高的膳食纤维和叶酸摄入量有关。在“饮酒者”模式上得分高的人也更有可能吸烟。“西方”饮食模式与男性和女性患结肠癌的风险增加有关。在67岁之前诊断的人群中（男性，比值比（OR）= 1.96，95%置信区间（CI）1.22-3.15;女性，OR = 2.02，95% CI 1.21-3.36）和远端肿瘤男性中（OR = 2.25，95% CI 1.47-3.46），这种相关性最强。“谨慎”饮食具有保护作用，在67岁之前确诊的人中观察到最强的相关性（男性：OR = 0.63，95% CI 0.43-0.92;女性：OR = 0.58，95% CI 0.38-0.87）;在近端肿瘤患者中，与这种饮食模式的相关性也很强（男性：OR = 0.55，95% CI 0.38-0.80;女性：OR = 0.64，95% GI 0.45-0.92）。虽然“替代品”（用低脂乳制品代替高脂乳制品，用人造黄油代替缓冲液，用家禽代替红肉，用全谷物代替精制谷物）患结肠癌的风险降低，但风险的降低并不具有统计学意义。这些数据支持这样的假设，即总体饮食摄入模式与结肠癌相关，并且与风险增加最大相关的饮食模式是典型的西式饮食。
Colon cancer has been associated with several nutrients and foods. The authors used data from a population-based study conducted in Northern California, Utah, and Minnesota to examine associations between dietary eating patterns and risk of developing colon cancer. Through factor analysis, detailed dietary intake data obtained from 1,993 cases (diagnosed in 1991-1994) and 2,410 controls were grouped into factors that were evaluated for relations with lifestyle characteristics and colon cancer risk. Several dietary patterns emerged. The dietary patterns with the most variation were labeled "Western," "prudent," "high fat/sugar dairy," "substituters," and "drinkers." The "Western" dietary pattern was associated with a higher body mass index and a greater intake of total energy and dietary cholesterol. The "prudent" pattern was associated with higher levels of vigorous leisure time physical activity, smaller body size, and higher intakes of dietary fiber and folate. Persons who had high scores on the "drinker" pattern were also more likely to smoke cigarettes. The "Western" dietary pattern was associated with an increased risk of colon cancer in both men and women. The association was strongest among people diagnosed prior to age 67 years (for men, odds ratio (OR) = 1.96, 95% confidence interval (CI) 1.22-3.15;.for women, OR = 2.02, 95% CI 1.21-3.36) and among men with distal tumors (OR = 2.25, 95% CI 1.47-3.46). The "prudent" diet was protective, with the strongest associations being observed among people diagnosed prior to age 67 years (men: OR = 0.63, 95% CI 0.43-0.92; women: OR = 0.58, 95% CI 0.38-0.87); associations with this dietary pattern were also strong among persons with proximal tumors (men: OR = 0.55, 95% CI 0.38-0.80; women: OR = 0.64, 95% GI 0.45-0.92). Although "substituters" (people who substituted low fat dairy products for high fat dairy products, margarine for buffer, poultry for red meat, and whole grains for refined grains) were at reduced risk of colon cancer, the reduction in risk was not statistically significant. These data support the hypothesis that overall dietary intake pattern is associated with colon cancer, and that the dietary pattern associated with the greatest increase in risk is the one which typifies a Western-style diet.