Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats
Effect of short- vs. long-term estrogen on reinstatement of cocaine-seeking behavior in female rats
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DOI：
10.1016/j.pbb.2005.07.015
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发表时间：
2005-09-01
影响因子：
3.6
通讯作者：
Carroll, ME
中科院分区：
文献类型：
--
作者：
Larson, EB;Roth, ME;Carroll, ME
在假手术、溶媒处理（SH+VEH）、去卵巢（OVX+VEH）和OVX+雌激素替代（OVX+EB）雌性Wistar大鼠中检查了雌激素对可卡因诱导的杠杆反应恢复的影响。在实验1和2中分别比较了长期（64 ± 1.56天）和短期（9天）EB治疗对可卡因寻求行为恢复的影响，以比较当EB在可卡因寻求行为的发展与恢复表达期间存在时的EB的影响。训练大鼠自我给予0.4 mg/kg/inf可卡因。在满足采集标准后，大鼠继续对可卡因作出反应，持续2小时/天，持续14天的维持期。然后用生理盐水代替CoCl 3，并开始21天的消退期。随后，在每天交替注射生理盐水或可卡因后，测试大鼠对先前药物配对杠杆的杠杆反应的恢复。在这两个实验中，在训练、维持或消退期间，两组之间的自我管理行为没有差异。在实验1中，SH+VEH和慢性治疗OVX+EB大鼠比OVX+VEH大鼠有更大的可卡因诱导的恢复。在实验2中，与OVX+VEH大鼠相比，短期治疗的OVX+EB大鼠也显示出增强的可卡因诱导的恢复。结果表明，EB介导的可卡因诱导的恢复增强依赖于EB的存在，在表达恢复，但不是在可卡因强化行为的发展过程中形成的刺激-奖励协会。(c)2005年爱思唯尔公司All rights reserved.
Estrogen effects on cocaine-induced reinstatement of lever responding were examined in sham-operated, vehicle-treated (SH+VEH), ovariectornized (OVX+VEH), and OVX female Wistar rats with estrogen replacement (OVX+EB). The effect of long- (64 1.56 days) and short-term (9 days) EB treatment on reinstatement of cocaine-seeking behavior was compared in Experiment 1 and 2, respectively, in order to compare the effect of EB when it was present during the development vs. expression of reinstatement of cocaine-seeking behavior. Rats were trained to self-administer 0.4 mg/kg/inf cocaine. After the acquisition criteria were met, rats continued to respond for cocaine for 2 h/day for a 14-day maintenance period. Cocaine was then replaced with saline and the 21-day extinction period commenced. Subsequently, rats were tested for reinstatement of lever responding on the previously drug-paired lever after alternating daily injections of saline or cocaine. In both experiments, there were no differences between groups in self-administration behavior during training, maintenance, or extinction. In Experiment 1, SH+VEH and chronically treated OVX+EB rats had greater cocaine-induced reinstatement than OVX+VEH rats. In Experiment 2, short-term treated OVX+EB rats also showed enhanced cocaine-induced reinstatement compared to OVX+VEH rats. The results indicate that EB-mediated enhancement of cocaine-induced reinstatement is dependent on EB presence during the expression of reinstatement but not during the formation of stimulus-reward associations during the development of cocaine-reinforced behavior. (c) 2005 Elsevier Inc. All rights reserved.