Inferring selective history from multilocus frequency data: Wright meets the Hamiltonian.
Inferring selective history from multilocus frequency data: Wright meets the Hamiltonian.
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从多位点频率数据推断选择性历史：赖特满足哈密顿量。
DOI：
10.1093/genetics/132.1.277
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发表时间：
1992
期刊：
影响因子：
3.3
通讯作者：
Hastings,A
中科院分区：
文献类型：
--
作者：
Fox,GA;Hastings,A
我们描述了一种在不指定先验选择形式的情况下研究多位点群体遗传模型动力学特征的方法。我们的方法包括指定初始和最终的基因频率(全部或部分)，然后根据连续时间遗传模型确定从初始状态到最终状态的最短时间，并对选择的强度和可能的形式进行任意限制。在用这种方法分析两个座位、两个等位基因模型时，我们证明了--只要r不比S大很多--在几百代的连锁平衡的初始状态下就可以产生实质性的连锁不平衡。我们还表明，除非重组比选择大得多，否则达到指定状态的最短时间对r的依赖性很弱。因此，相似的选择强度可以在固定的时间和一系列小的重组率上导致类似的不平衡水平。这意味着，在单个基因的水平上，通常不能假设选择导致重组率和不平衡水平之间的任何特定关系。我们指出了我们的方法在提出理论问题和解释数据时的许多其他有用的方法。
We describe a method to study characteristics of the dynamics of multilocus population genetic models without specifying the form of selection a priori. Our approach consists of specifying initial and final genotypic frequencies (either completely or partially) and then determining the minimum time to go from the initial condition to the final condition according to a continuous time genetic model, with arbitrary constraints on the strength and possibly the form of selection. In analyzing a two-locus, two-allele model with this approach, we show that--so long as r is not much larger than s--substantial linkage disequilibrium can be generated from an initial state of linkage equilibrium in a few hundred generations. We also show that unless recombination is much larger than selection, there is only weak dependence on r of the minimum time to reach a specified state. Thus, similar strengths of selection can lead to similar levels of disequilibrium over a fixed time and a range of small recombination rates. This implies that, within the level of a single gene, selection cannot in general be assumed to lead to any particular relationship between recombination rate and levels of disequilibrium. We indicate a number of other ways in which our method can be useful in asking theoretical questions and in interpreting data.