Perceptual attentional set-shifting is impaired in rats with neurotoxic lesions of posterior parietal cortex
Perceptual attentional set-shifting is impaired in rats with neurotoxic lesions of posterior parietal cortex
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DOI：
10.1523/jneurosci.23-02-00676.2003
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发表时间：
2003-01-15
影响因子：
5.3
通讯作者：
Baxter, MG
中科院分区：
文献类型：
--
作者：
Fox, MT;Barense, MD;Baxter, MG
后顶叶皮层（PPC）被认为参与空间信息的表征，包括空间注意加工。由于PPC与参与注意力和执行功能的额叶皮层区域广泛相关，我们试图确定PPC是否参与非空间注意力过程，例如它投射到的额叶区域。内侧额叶皮层（大鼠）或外侧前额叶皮层（非人类灵长类动物）的损伤会削弱将注意力从刺激的一个感知维度转移到另一个感知维度的能力（称为额外维度转移）。在注意力转移范式中测试的PPC神经毒性病变的大鼠表现出与内侧额叶皮层病变的大鼠相同的损伤模式：它们在任务的额外维度转移阶段选择性受损。在任务的其他阶段的表现与对照组大鼠没有区别，包括逆转先前学习的歧视的能力。这些发现与模型一致，该模型将PPC分配给皮层注意力处理网络中的重要角色，以及PPC在处理预期和惊喜信息中的作用。重要的是，他们还表明，PPC和额叶皮层之间的相互作用不仅限于空间注意力处理。
The posterior parietal cortex (PPC) is believed to be involved in the representation of spatial information, including spatial attentional processing. Because the PPC is extensively interconnected with frontal cortical regions involved in attention and executive function, we sought to determine whether PPC was involved in nonspatial attentional processes such as those of the frontal areas to which it projects. Lesions of the medial frontal cortex (in rats) or lateral prefrontal cortex (in nonhuman primates) impair the ability to shift attention from one perceptual dimension of a stimulus to another (referred to as an extradimensional shift). Rats with neurotoxic lesions of the PPC tested in an attentional set-shifting paradigm demonstrated a pattern of impairment identical to that of rats with medial frontal cortex lesions: they were selectively impaired on the extradimensional shift phase of the task. Performance in other phases of the task was indistinguishable from that of control rats, including the ability to reverse a previously learned discrimination. These findings are consistent with models that assign the PPC a prominent role in cortical attentional processing networks, as well as a role for the PPC in processing information about expectancy and surprise. They also suggest, importantly, that the interaction between the PPC and the frontal cortex is not limited to spatial attentional processing.