Hepatic histology in hepatitis C virus carriers coinfected with hepatitis G virus
Hepatic histology in hepatitis C virus carriers coinfected with hepatitis G virus
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DOI：
10.1136/gut.42.1.103
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发表时间：
1998-01-01
期刊：
影响因子：
24.5
通讯作者：
Alexander, GJM
中科院分区：
文献类型：
--
作者：
Petrik, J;Guella, L;Alexander, GJM
Background-A novel flavivirus has been described recently and designated hepatitis G virus (HGV). The virus is transmitted by the parenteral route but it is uncertain whether it is associated with chronic liver disease because Liver biopsy is difficult to justify in this group.Aims-To examine histological features of liver biopsy in patients infected with hepatitis C virus (HCV) according to the presence or absence of HCV and HGV RNA.Methods-One hundred and thirty one consecutive HCV carriers undergoing staging liver biopsy were studied retrospectively. In each, HCV RNA and HGV RNA were detected by reverse transcription polymerase chain reaction on serum samples collected at the time of biopsy. The presence of each RNA was correlated with histological features blind to the RNA results; individual histological features of inflammation or fibrosis were scored separately,Results-Nineteen patients were positive for both HGV and HCV RNA in serum, 91 were positive for HCV RNA alone, two were positive for HGV RNA alone, and 19 were negative for both RNA species. Neither age nor sex differed between the groups; a greater proportion of intravenous drug users were HGV RNA positive, but this was not statistically significant. There was no effect of HGV coinfection on the stage of fibrosis or any other histological parameter except steatosis; patients with HCV and HGV RNA had a higher mean score for fat than those patients with HCV RNA alone (p
