Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy
Preparation and radiolabeling of surface-modified magnetic nanoparticles with rhenium-188 for magnetic targeted radiotherapy
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DOI：
10.1016/j.jmmm.2003.10.022
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发表时间：
2004-06-01
影响因子：
2.7
通讯作者：
Häfeli, UO
中科院分区：
文献类型：
--
作者：
Cao, JQ;Wang, YX;Häfeli, UO
合成了包覆二氧化硅的磁铁矿纳米颗粒，并用SEM、TEM和XRD对其进行了表征。用氨基硅烷偶联剂N-[3-（三甲基氧基硅基）丙基]-乙二胺（SG-Si900）对组氨酸进行表面修饰后，以戊二醛为交联剂与胺基共价连接。然后用Re-188对磁性纳米粒子进行放射性标记，标记率为91.4 +/- 0.3%，体外稳定性好。标记机制为fac-[Re-188(CO)(3)(H2O)(3)]（+）核与咪唑基络合。(C) 2003 Elsevier B.V.版权所有
Magnetite nanoparticles coated with silica were synthesized and characterized by electron microscopic methods (SEM and TEM) and crystal structure analysis (XRD). After surface modification with an amino silane coupling agent, N-[3-(trimethyoxysilyl) propyl]-ethylenediamine (SG-Si900), histidine was covalently linked to the amine group using glutaraldehyde as cross.-linker. The magnetic nanoparticles were then radiolabeled with Re-188 with a labeling yield of 91.4 +/- 0.3% and good stability in vitro. The labeling mechanism is suggested as fac-[Re-188(CO)(3)(H2O)(3)](+) core complexed with imidazolyl groups. (C) 2003 Elsevier B.V. All rights reserved.