Chemical sex drugs regulate HIV infection and replication in immune cells: a vicious circle
Chemical sex drugs regulate HIV infection and replication in immune cells: a vicious circle
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化学性药物调节免疫细胞中的艾滋病毒感染和复制：恶性循环。
DOI：
10.1097/qad.0000000000002708
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发表时间：
2021-01-01
期刊：
影响因子：
3.8
通讯作者：
Wang, Kun-Hua
中科院分区：
文献类型：
--
作者：
Lu, Danfeng;Sun, Hua;Wang, Kun-Hua
吸毒是人类免疫缺陷病毒（HIV）感染和传播的重要因素。临床研究表明，即使在坚持抗逆转录病毒治疗 (ART) 的患者中，药物使用也可能会增加病毒载量、加速疾病进展并加剧获得性免疫缺陷综合征 (AIDS) 相关的死亡 [1, 2]。吸毒会导致促进艾滋病毒传播的危险行为，例如共用针头或注射器，从而增加感染艾滋病毒的滥用者的数量。化学性（chemsex）药物是新型精神活性物质和性增强剂，包括可卡因、甲基苯丙胺、摇头丸、氯胺酮、“Magu”丸、g-羟基丁酸（GHB）、甲氧麻黄酮、勃起功能障碍剂和poppers [3, 4]。长期使用化学性药物进行性活动会导致直肠创伤或阴茎擦伤，从而显着增加感染包括艾滋病毒在内的性传播疾病的风险。 Chemsex 吸毒还与高风险性行为有关，例如拥有多个性伴侣、性行为时不经常使用安全套以及从事同性恋或群体性行为 [3, 5]。
Drug use is an important factor in human immunodeficiency virus (HIV) infection and transmission. Clinical studies have shown that even among antiretroviral therapy (ART) adherent patients, drug use may increase the viral load, accelerate disease progression, and worsen acquired immune deficiency syndrome (AIDS)-related deaths [1, 2]. Drug use leads to risky behaviors that promote HIV transmission, such as sharing needles or syringes, hence increasing the number of HIV-infected abusers. Chemical sex (chemsex) drugs are new psychoactive substances and sex enhancers including cocaine, methamphetamine, ecstasy, ketamine,‘Magu’pills, g-hydroxybutyric acid (GHB), mephedrone, erectile dysfunction agents and poppers [3, 4]. A long-term sexual activity using chemsex drugs leads to rectal trauma or penile abrasions, which significantly increase the risk of infection of sexually transmitted diseases including HIV. Chemsex drug use is also associated with high-risk sexual behaviors, such as having multiple sexual partners, inconsistent use of condoms during sex and engaging in homosexual or group sex [3, 5].