Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline.
Vascular Senescence: A Potential Bridge Between Physiological Aging and Neurogenic Decline.
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DOI：
10.3389/fnins.2021.666881
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发表时间：
2021
影响因子：
4.3
通讯作者：
Fariñas I
中科院分区：
文献类型：
--
作者：
Rojas-Vázquez S;Blasco-Chamarro L;López-Fabuel I;Martínez-Máñez R;Fariñas I
成年哺乳动物大脑包含独特的神经源性生态位，其中含有神经干细胞（NSC）群，能够在一生中维持特定神经元亚型的产生。然而，它们产生新后代的能力随着年龄的增长而下降。这些特殊生态位的微环境提供了多种细胞和分子信号，调节 NSC 的行为和潜力。在不同的生态位组成部分中，脉管系统由于其在 NSC 调节中不可否认的作用及其增强神经发生的治疗潜力，多年来引起了越来越多的兴趣。 NSC 具有独特的定位，可以接收局部分泌的因子和源自血管元件的粘附介导的信号。此外，联体共生研究表明，神经干细胞还暴露于血源性因子，对体循环进行感知和响应。随着年龄的增长，血管系统在细胞水平上会发生结构和功能的变化，这可能会影响 NSC 的适当外在调节。此外，异时性共生体的血液交换实验表明，与年龄相关的血液成分变化也会导致老年人的成人神经发生障碍。尽管血管或血液来源的信号传导在衰老过程中的机制尚不完全清楚，但生物体衰老的一个普遍特征是衰老细胞的积累，这些细胞是炎症和其他有害信号的来源，可能对邻近细胞产生负面影响。本综述重点关注衰老过程中血管衰老、循环促衰老因子和 NSC 潜力下降之间的相互作用。了解衰老大脑中 NSC 动力学的机制可能会带来新的治疗方法，其中可能包括衰老作用，以针对年龄依赖性大脑衰退。
The adult mammalian brain contains distinct neurogenic niches harboring populations of neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of neurons during the lifetime. However, their ability to produce new progeny declines with age. The microenvironment of these specialized niches provides multiple cellular and molecular signals that condition NSC behavior and potential. Among the different niche components, vasculature has gained increasing interest over the years due to its undeniable role in NSC regulation and its therapeutic potential for neurogenesis enhancement. NSCs are uniquely positioned to receive both locally secreted factors and adhesion-mediated signals derived from vascular elements. Furthermore, studies of parabiosis indicate that NSCs are also exposed to blood-borne factors, sensing and responding to the systemic circulation. Both structural and functional alterations occur in vasculature with age at the cellular level that can affect the proper extrinsic regulation of NSCs. Additionally, blood exchange experiments in heterochronic parabionts have revealed that age-associated changes in blood composition also contribute to adult neurogenesis impairment in the elderly. Although the mechanisms of vascular- or blood-derived signaling in aging are still not fully understood, a general feature of organismal aging is the accumulation of senescent cells, which act as sources of inflammatory and other detrimental signals that can negatively impact on neighboring cells. This review focuses on the interactions between vascular senescence, circulating pro-senescence factors and the decrease in NSC potential during aging. Understanding the mechanisms of NSC dynamics in the aging brain could lead to new therapeutic approaches, potentially include senolysis, to target age-dependent brain decline.
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影响因子：
4.6
作者：
Daynac M;Morizur L;Chicheportiche A;Mouthon MA;Boussin FD
通讯作者：
Boussin FD
DOI：
10.1146/annurev-pathol-121808-102144
发表时间：
2010
期刊：
Annual review of pathology
影响因子：
--
作者：
Coppé JP;Desprez PY;Krtolica A;Campisi J
通讯作者：
Campisi J
影响因子：
9
作者：
通讯作者：
--
影响因子：
5.3
作者：
Crouch, Elizabeth E.;Liu, Chang;Doetsch, Fiona
通讯作者：
Doetsch, Fiona
影响因子：
16.2
作者：
Delgado, Ana C.;Ferron, Sacri R.;Farinas, Isabel
通讯作者：
Farinas, Isabel