Compensatory mechanisms in rats with nasal obstructions.
Compensatory mechanisms in rats with nasal obstructions.
复制标题
鼻塞大鼠的代偿机制。
DOI：
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发表时间：
1994
期刊：
影响因子：
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通讯作者：
S. Arslan
中科院分区：
文献类型：
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作者：
M. Erkan;E. Erhan;A. Sağlam;S. Arslan
这项在大鼠中进行的研究旨在证明呼吸动力学的变化对鼻塞的代偿作用。该实验在 30 只大鼠身上进行。 15只大鼠作为研究组，另外10只大鼠作为对照组。 30 只老鼠中的 5 只接受了手术，以确定它们是否能活，如果能活，能活多久。张口呼吸引起急性呼吸性酸中毒和明显的吞气，导致5只实验动物术后90至100小时自然死亡。由于腭-会厌近似导致口咽气道狭窄，被认为是鼻阻塞大鼠呼吸功能不全的原因。口咽气道阻力高引起的呼吸力学的代偿性变化，加上一些可能的反射变化，可能导致了空气吞咽。据推测，胃和肠道内的空气量增加，导致膈肌升高和麻痹性肠梗阻，从而导致死亡。在这些动物中没有观察到误吸的迹象。双鼻孔手术阻塞后，15 只研究大鼠在术后 24、48 和 72 小时发生酸碱平衡变化。在第一、第二天和第三天，观察到 pO2 和 pH 值降低，pCO2 升高，血清碳酸氢盐代偿性升高。
This study, in rats was designed to demonstrate the changes in respiratory dynamics in compensation for nasal obstructions. The experiment was performed on 30 rats. Fifteen rats served as the study group while another 10 rats served as controls. Five of the 30 rats were operated on to find out whether they would live and if so, for how long. Mouth breathing caused acute respiratory acidosis and marked aerophagia, leading to spontaneous death of the five experimental animals 90 to 100 hours postoperatively. Stenosis of the oropharyngeal airway due to palatal-epiglottic approximation, is supposed to be responsible for the respiratory insufficiency in nasally-obstructed rats. The compensatory changes in respiratory mechanics caused by high oropharyngeal airway resistance, together with some possible reflex changes, may have caused air swallowing. It is supposed that the increased air volume in the stomach and guts, causing elevation of the diaphragm and a paralytic ileus, contributed to mortality. No signs of aspiration were observed in these animals. After the surgical obstruction of both nostrils, changes in acid-base balance occurred in the 15 study rats 24, 48, and 72 hours postoperatively. On the first, second, and third days, a decrease in pO2 and pH, an increase in pCO2, and a compensatory increase in serum bicarbonate was observed.