Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution
Impaired brain development in the rat following prenatal exposure to methylazoxymethanol acetate at gestational day 17 and neurotrophin distribution
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DOI：
10.1097/01.wnr.0000135934.03635.6a
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发表时间：
2004-08-06
期刊：
影响因子：
1.7
通讯作者：
Aloe, L
中科院分区：
文献类型：
--
作者：
Fiore, M;Grace, AA;Aloe, L
包括精神分裂症在内的几种神经精神障碍是中枢神经系统发育中断的结果。因此，宫内暴露于毒素可能会增加患精神病的风险。我们调查了大鼠出生前暴露于神经毒素甲氧基甲醇醋酸酯是否会导致脑神经营养素水平的长期变化。我们测定了幼年和成年大鼠脑内神经生长因子和脑源性神经营养因子的水平。顶叶皮质神经生长因子或脑源性神经营养因子减少，同时海马区和内嗅皮层的神经营养素含量改变。这项研究首次显示了单次产前暴露于神经毒素对成人脑区神经营养素水平的长期影响，这些脑区与神经精神障碍有关。
Several neuropsychiatric disorders, including schizophrenia, are the consequence of a disrupted development of the CNS. Accordingly, intrauterine exposure to toxins may increase the risk for psychopathology. We investigated whether prenatal exposure of rats to the neurotoxin methylaxoxymethanol acetate led to long-term changes in cerebral neurotrophin levels. We measured the brain levels of nerve growth factor and brain derived neurotrophic factor in young adult and adult rats. Decreased nerve growth factor or brain derived neurotrophic factor were found in the parietal cortex accompanied by altered neurotrophin content in the hippocampus and entorhinal cortex. The present study is the first to show long-lasting effects of a single prenatal exposure to a neurotoxin on adult levels of neurotrophins in brain regions implicated in neuropsychiatric disorders.