Montelukast therapy and psychological distress in chronic obstructive pulmonary disease (COPD): A preliminary report
Montelukast therapy and psychological distress in chronic obstructive pulmonary disease (COPD): A preliminary report
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DOI：
10.1016/j.archger.2010.04.014
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发表时间：
2011-01-01
影响因子：
4
通讯作者：
Cacciafesta, Mauro
中科院分区：
文献类型：
--
作者：
Gueli, Nicolo;Verrusio, Walter;Cacciafesta, Mauro
慢性阻塞性肺疾病（COPD）是一种慢性阻塞性肺疾病，患者的呼吸功能、运动能力和健康状况逐渐下降，其特征是炎性细胞因子如TNF-α、LTB 4、IL-8等增加。在本研究中，我们考虑了20例稳定型COPD患者（15例男性和5例女性;平均年龄：72.8 ± 6.3）。所有患者均在入组时进行心理应激评估，并给予白三烯受体拮抗剂（孟鲁司特片）10 mg/d治疗12个月。12个月后，我们观察到血清LTB 4、IL-8水平显著降低，门诊就诊次数、住院次数和住院时间也减少。(C)2010爱思唯尔爱尔兰有限公司版权所有。
Chronic obstructive pulmonary disease (COPD) is an alteration in which ventilatory function, exercise capacity and health status of patients progressively decline and it is characterized by an increase of inflammatory cytokines such as TNF-alpha, LTB4, IL-8, etc. In this study we considered twenty patients (15 males and 5 females; mean age: 72.8 +/- 6.3) with stable COPD. All patients were performed evaluation of psychological stress at enrollment and were treated with leukotriene receptor antagonists (montelukast tablets) 10 mg/day for 12 months. After 12 months we observed a significant decrease of serum levels of LTB4, IL-8 and also a decrease of the number of outpatient clinic visits, of the number of hospitalizations and of the duration of hospitalization. (C) 2010 Elsevier Ireland Ltd. All rights reserved.