Synthesis and Pharmacological Activities of Novel 3‐(Isoxazol‐3‐yl)‐quinazolin‐4(3H)‐one Derivatives
Synthesis and Pharmacological Activities of Novel 3‐(Isoxazol‐3‐yl)‐quinazolin‐4(3H)‐one Derivatives
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DOI：
10.1002/(sici)1521-4184(19993)332:2
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发表时间：
1999-03
影响因子：
5.1
通讯作者：
G. Daidone;D. Raffa;B. Maggio;F. Plescia;V. Cutuli;N. Mangano;A. Caruso
中科院分区：
文献类型：
--
作者：
G. Daidone;D. Raffa;B. Maggio;F. Plescia;V. Cutuli;N. Mangano;A. Caruso
合成了几种新的3-（异恶唑-3-基）-喹唑啉-4（3 H）-酮衍生物，并测试了它们的镇痛和抗炎活性，以及它们的急性毒性和致溃疡作用。少数化合物在扭体试验和醋酸性腹膜炎试验中与保泰松活性相当。它们具有非常低的致溃疡作用。
Several new 3‐(isoxazol‐3‐yl)‐quinazolin‐4(3H)‐one derivatives were synthesized and tested for their analgesic and antiinflammatory activities, as well as for their acute toxicity and ulcerogenic effect. A few compounds were as active as phenylbutazone in the writhing and acetic acid peritonitis tests. They had a very low ulcerogenic effect.