Transcriptional regulation of erythropoiesis.
Transcriptional regulation of erythropoiesis.
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DOI：
10.11406/rinketsu.58.643
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发表时间：
2017
期刊：
影响因子：
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通讯作者：
T. Fujiwara
中科院分区：
文献类型：
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作者：
T. Fujiwara
造血细胞分化受多种谱系特异性转录因子的调控。在红系分化的背景下，GATA-1的重要性已被基于细胞的体外分析以及敲除小鼠模型和罕见的贫血患者明确地证明。GATA-1通过双锌指基序识别DNA结合一致序列[(A/T)GATA(A/G)]，调节红系相关基因的表达，如珠蛋白和参与血红素生物合成的基因。GATA-1与基础螺旋-环-螺旋转录因子SCL/TAL1形成复合体，SCL/TAL1是另一种主要的造血调节因子。SCL/TAL1形成一个包含LMO2、LDB1和ETO2的复合体，它们都是红系分化过程中GATA-1活性所必需的。在这里，我们重点介绍目前对红细胞生成转录调控的理解。
Hematopoietic cell differentiation is regulated by various lineage-specific transcription factors. In the context of erythroid differentiation, the importance of GATA-1 has been unequivocally demonstrated by cell-based ex vivo assays, as well as knockout mouse models and rare patients with anemias. GATA-1 regulates the expression of erythroid-related genes, such as globins and genes involved in heme biosynthesis, by recognizing the DNA binding consensus sequence [(A/T) GATA (A/G)] through dual zinc finger motifs. GATA-1 forms a complex with the basic helix-loop-helix transcription factor SCL/TAL1, another master regulator of hematopoiesis. SCL/TAL1 forms a complex containing LMO2, LDB1, and ETO2, which are all required for GATA-1 activity during the erythroid differentiation. Here we focus on the current understanding of transcriptional regulation of erythropoiesis.