A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly.
A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly.
复制标题
对老年人的非甾体类抗炎药物的全面综述。
DOI：
10.14336/ad.2017.0306
复制
发表时间：
2018-03
影响因子：
7.4
通讯作者：
Rangaswami J
中科院分区：
文献类型：
--
作者：
Wongrakpanich S;Wongrakpanich A;Melhado K;Rangaswami J
NSAID，非甾体抗炎药，是最常用的处方止痛药之一。它是用于疼痛和炎症的高效药物类别;然而，NSAID已知有多种不良反应，包括胃肠道出血、心血管副作用和NSAID诱导的肾毒性。随着我们社会的老龄化，对老年人群中这类药物的全面了解至关重要。因此，我们回顾了非甾体抗炎药的药效学和药代动力学，目前的指南使用，不良反应的档案，药物相互作用的非甾体抗炎药和常用药物在老年人。
NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly.