CA2 orchestrates hippocampal network dynamics.
CA2 orchestrates hippocampal network dynamics.
复制标题
CA2 协调海马网络动态。
DOI：
10.1002/hipo.23495
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发表时间：
2023
期刊：
影响因子：
3.5
通讯作者：
Karaba,LindsayA
中科院分区：
文献类型：
--
作者：
Oliva,Azahara;Fernandez-Ruiz,Antonio;Karaba,LindsayA
海马体由不同的亚区组成：CA1、CA2、CA3和齿状回。尽管有丰富的海马区研究文献，但直到最近，CA2才得到很少的关注。新的遗传和生理工具的发展使得最近的研究能够表征这一海马亚区的独特属性和功能作用。尽管CA2的体积很小，但其细胞内的含量在分子和生理水平上是不同的。CA2与包括社会记忆在内的社会行为密切相关。更广泛地说，海马体参与记忆的机制包括在经历后重新激活神经元群。此过程由称为尖波波动(SWR)的同步网络事件协调。最近的证据表明，CA2在SWR的产生中起着重要作用。CA2锥体细胞独特的连接和生理特性使该区域成为海马区信息处理的核心计算中心。在这里，我们回顾了最近的发现，从系统神经科学的角度支持CA2在协调海马网络动态中的作用。
The hippocampus is composed of various subregions: CA1, CA2, CA3, and the dentate gyrus (DG). Despite the abundant hippocampal research literature, until recently, CA2 received little attention. The development of new genetic and physiological tools allowed recent studies characterizing the unique properties and functional roles of this hippocampal subregion. Despite its small size, the cellular content of CA2 is heterogeneous at the molecular and physiological levels. CA2 has been heavily implicated in social behaviors, including social memory. More generally, the mechanisms by which the hippocampus is involved in memory include the reactivation of neuronal ensembles following experience. This process is coordinated by synchronous network events known as sharp‐wave ripples (SWRs). Recent evidence suggests that CA2 plays an important role in the generation of SWRs. The unique connectivity and physiological properties of CA2 pyramidal cells make this region a computational hub at the core of hippocampal information processing. Here, we review recent findings that support the role of CA2 in coordinating hippocampal network dynamics from a systems neuroscience perspective.