THE PHENOMENON OF THE ACUTE PHASE RESPONSE
THE PHENOMENON OF THE ACUTE PHASE RESPONSE
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DOI：
10.1111/j.1749-6632.1982.tb22124.x
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发表时间：
1982-01-01
影响因子：
5.2
通讯作者：
KUSHNER, I
中科院分区：
文献类型：
--
作者：
KUSHNER, I
在日常生活的唐斯中，生理稳态的维持是由许多生理机制保证的。然而，有时会发生干扰事件-组织损伤和感染-这对有机体的完整性构成威胁，似乎需要重新调整通常的代谢和生理平衡。组织对这种损伤或感染的局部反应是急性炎症;其主要临床表现是由于血管口径和流量的变化、血管通透性增加和白细胞的吸引。在炎症反应中起作用的机制一直是深入研究的主题;其中许多已在Weissman和Kaplan博士的先前论文中描述。此外，在损伤后的最初几天内，发生了大量的全身和代谢变化：急性期反应。从目的论的观点来看，我们必须假设，全身性的急性期反应在帮助受伤后的一段时间内存活方面是有价值的，并且在实现与局部炎症反应相同的目标方面是有价值的：遏制或破坏感染因子，清除受损组织，修复受影响的器官。对人类急性期反应的研究通常仅限于组织损伤的单一原因，例如感染（有时仅限于特定感染），
The maintenance of physiologic homeostasis during the ups and downs of daily living is assured by a number of physiologic mechanisms. From time to time, however, perturbing events occur-tissue injury and infection-which represent a threat to the integrity of the organism, and appear to require readjustments in the usual metabolic and physiologic equilibria. The local response of tissue to such injury or infection is acute inflammation; its major clinical manifestations result from changes in vascular caliber and flow, increased vascular permeability, and attraction of leukocytes.’The mechanisms which play a role in the inflammatory response have been the subject of intense investigative effort; many of them have been described in the preceding papers by Drs. Weissman and Kaplan. In addition, during the first few days following insult, a vast number of systemic and metabolic changes occur: the acute phase response. From a teleological point of view one must assume that the systemic, acute phase response is of value in helping to permit survival during the period immediately following injury, and in achieving the same goals as the local inflammatory response does: containment or destruction of infectious agents, removal of damaged tissue, and repair of the affected organ. Studies of the acute phase response in man have usually been limited to single causes of tissue injury, eg, infection,(and at times only specific infections),