Gender differences in two forms of cold-water swim analgesia
Gender differences in two forms of cold-water swim analgesia
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两种冷水游泳镇痛形式的性别差异
DOI：
10.1016/s0031-9384(86)80009-9
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发表时间：
1986
影响因子：
2.9
通讯作者：
R. Bodnar
中科院分区：
文献类型：
--
作者：
M. Romero;R. Bodnar
雌性大鼠比雄性大鼠表现出较低的休克阈值和较少的吗啡镇痛，这些差异对性腺操作敏感。雌性大鼠的动情周期中，基线疼痛阈值和吗啡镇痛也有所不同。第一个实验表明，“非阿片类药物”连续冷水游泳（CCWS：2°C，3.5 分钟）镇痛和“阿片类药物”间歇性冷水游泳（ICWS：2°C，18 次 10 秒游泳和 3 分钟内休息 10 秒）镇痛会受到性别特异性的影响。与年龄匹配或体重匹配的雄性大鼠相比，雌性大鼠的 CCWS 和 ICWS 镇痛强度显着较低。跳跃测试显示出比甩尾测试更一致的模式。第二个实验未能显示 CCWS 镇痛程度在女性发情周期中的差异。这些数据表明阿片类药物（ICWS）和非阿片类药物（CCWS）形式的应激镇痛对性别差异敏感，并表明男性性腺激素可能增强镇痛反应性。
Female rats display lower shock thresholds and less morphine analgesia than male rats, differences which are sensitive to gonadal manipulations. Baseline pain thresholds and morphine analgesia also vary across the estrous cycle of female rats. The first experiment demonstrated that ‘nonopiod’ continuous cold-water swim (CCWS: 2°C for 3.5 min) analgesia and ‘opioid’ intermittent cold-water swim (ICWS: 2°C, 18 10-sec swims and 10-sec rests over 3 min) analgesia are subject to gender-specific effects. The magnitudes of CCWS and ICWS analgesia were significantly lower in female rats as compared to either age-matched or weight-matched male rats. The jump test displayed a more consistent pattern than the tail-flick test. The second experiment failed to show differences in the magnitude of CCWS analgesia across the female estrous cycle. These data demonstrate that both opioid (ICWS) and nonopioid (CCWS) forms of stress-induced analgesia are sensitive to gender differences, and suggest that male gonadal hormones may enhance analgesic responsivity.