Carotid intima media thickness and low high-density lipoprotein (HDL) in South Asian immigrants: could dysfunctional HDL be the missing link?
Carotid intima media thickness and low high-density lipoprotein (HDL) in South Asian immigrants: could dysfunctional HDL be the missing link?
复制标题
DOI：
10.5114/aoms.2014.46208
复制
发表时间：
2014-10-27
期刊：
影响因子：
--
通讯作者：
Reddy ST
中科院分区：
文献类型：
--
作者：
Dodani S;Dong L;Guirgis FW;Reddy ST
与其他种族人群相比，美国的南亚移民（SAIs）显示出更高的冠状动脉疾病（CAD）患病率及其危险因素。传统的CAD风险因素不能解释过度的CAD风险;因此，有必要确定其他标志物，可以预测高风险SAI中CAD的未来风险。本研究的目的是使用颈总动脉内膜中层厚度（CCA-IMT）评估亚临床CAD的存在及其与代谢综合征（MS）和促炎性/功能障碍性HDL（Dys-HDL）的相关性。对130名年龄在35-65岁之间的第一代最高审计机构进行了一项以社区为基础的研究。使用HDL炎症指数测定Dys-HDL。使用逻辑回归和Fisher精确检验完成分析。使用CCA-IMT ≥ 0.8 mm（作为替代标志物）的亚临床CAD发生率为31.46%。年龄和性别校正的CCA-IMT与2型糖尿病（p = 0.008）、高血压（p = 0.012）、高敏C反应蛋白（p < 0.001）和同型半胱氨酸（p = 0.051）显著相关。MS和Dys-HDL的存在与CCA-IMT显著相关，即使在年龄和性别调整后。Dys-HDL与CCA-IMT的比值为5倍（95%CI：1.68，10.78）。有必要探索和了解非传统的CAD风险因素，特别关注Dys-HDL，知道SAIs具有低HDL水平。这些信息不仅有助于对高风险的无症状SAI人群进行分层，而且从疾病管理的角度来看也是有用的。
South Asian immigrants (SAIs) in the US exhibit higher prevalence of coronary artery disease (CAD) and its risk factors compared with other ethnic populations. Conventional CAD risk factors do not explain the excess CAD risk; therefore there is a need to identify other markers that can predict future risk of CAD in high-risk SAIs. The objective of the current study is to assess the presence of sub-clinical CAD using common carotid artery intima-media thickness (CCA-IMT), and its association with metabolic syndrome (MS) and pro-inflammatory/dysfunctional HDL (Dys-HDL). A community-based study was conducted on 130 first generation SAIs aged 35–65 years. Dys-HDL was determined using the HDL inflammatory index. Analysis was completed using logistic regression and Fisher's exact test. Sub-clinical CAD using CCA-IMT ≥ 0.8 mm (as a surrogate marker) was seen in 31.46%. Age and gender adjusted CCA-IMT was significantly associated with type 2 diabetes (p = 0.008), hypertension (p = 0.012), high-sensitivity C-reactive protein (p < 0.001) and homocysteine (p = 0.051). Both the presence of MS and Dys-HDL was significantly correlated with CCA-IMT, even after age and gender adjustment. The odds of having Dys-HDL with CCA-IMT were 5 times (95% CI: 1.68, 10.78). There is a need to explore and understand non-traditional CAD risk factors with a special focus on Dys-HDL, knowing that SAIs have low HDL levels. This information will not only help to stratify high-risk asymptomatic SAI groups, but will also be useful from a disease management point of view.
登录
查看更多内容
影响因子：
8.3
作者：
Howard, G;Manolio, TA;OLeary, DH
通讯作者：
OLeary, DH
影响因子：
39.2
作者：
Hodis, HN;Mack, WJ;Azen, SP
通讯作者：
Azen, SP
DOI：
10.1161/01.atv.15.11.1987
发表时间：
1995-11-01
影响因子：
8.7
作者：
COCKERILL, GW;RYE, KA;BARTER, PJ
通讯作者：
BARTER, PJ
影响因子：
3.8
作者：
Gonzalez-Ortiz, M.;Martinez-Abundis, E.;Ramos-Zavala, M. G.
通讯作者：
Ramos-Zavala, M. G.
影响因子：
158.5
作者：
CLARKE, R;DALY, L;GRAHAM, I
通讯作者：
GRAHAM, I