Migraine in mitochondrial disorders: Prevalence and characteristics

Migraine in mitochondrial disorders: Prevalence and characteristics
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DOI：
10.1177/0333102417723568
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发表时间：
2018-05-01
期刊：
CEPHALALGIA
影响因子：
4.9
通讯作者：
Servidei, Serenella
Servidei, Serenella
中科院分区：
医学2区
文献类型：
--
作者：
Vollono, Catello;Primiano, Guido;Servidei, Serenella

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背景偏头痛是线粒体疾病（MD）的一个众所周知的特征。然而，没有系统的流行病学数据是在大的人群patients.Aims-这个横断面队列研究的目的是描述的患病率和偏头痛的特点，在一个大的队列患者线粒体脑myopathies.Methods我们研究了93个连续的患者与特征性MD提到我们的神经肌肉单位在12个月的时间。所有患者（年龄范围=16-78岁; 31名男子; 58例进行性眼外肌麻痹[PEO]，12例肌阵挛性癫痫伴粗糙红纤维[MERRF]，8例线粒体脑肌病、乳酸性酸中毒和卒中样发作[MELAS]，2例线粒体神经胃肠脑肌病[MNGIE]和13例其他MD）使用符合IHS标准的操作诊断工具进行结构化诊断性头痛访谈。如果他们符合偏头痛的标准，他们被纳入偏头痛组。其他患者计入无偏头痛组。研究了患者的人口统计学和偏头痛特征。结果35.5%的患者报告有偏头痛。无先兆偏头痛是最常见的头痛（81.8%）。偏头痛组年龄较小（P
Background Migraine is a well-known feature of mitochondrial disorders (MDs). However, no systematic epidemiological data are available in large populations of patients.Aims The aim of this cross-sectional cohort study was to describe the prevalence and migraine characteristics in a large cohort of patients with mitochondrial encephalomyopathies.Methods We studied 93 consecutive patients with characterised MDs referred to our Neuromuscular Unit during a 12-month period. All patients (age range=16-78 years; 31 men; 58 progressive external ophthalmoplegia [PEO], 12 myoclonic epilepsy with ragged red fibres [MERRF], eight mitochondrial encephalomyopathy, lactic acidosis and stroke-like episodes [MELAS], two mitochondrial neurogastrointestinal encephalomyopathy [MNGIE] and 13 other MDs) underwent a structured diagnostic headache interview using an operational diagnostic tool following the IHS criteria. If they met the criteria for migraine, they were included in the Migraine Group'. The other patients were counted in the No Migraine Group'. Patient demographic and migraine characteristics were examined. Clinical, neuroradiological and neurophysiological data were compared between groups.Results Migraine was reported in 35.5% of patients. Migraine without aura was the most common headache (81.8%). The migraine group showed younger age (P