A single locus regulates a female-limited color pattern polymorphism in a reptile
A single locus regulates a female-limited color pattern polymorphism in a reptile
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DOI：
10.1126/sciadv.abm2387
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发表时间：
2022-03-01
期刊：
影响因子：
13.6
通讯作者：
Uller, Tobias
中科院分区：
文献类型：
--
作者：
Feiner, Nathalie;Brun-Usan, Miguel;Uller, Tobias
动物的颜色通常以周期性的模式表达，这可能是由差异细胞迁移引起的，但这些过程是如何调节的仍然是难以捉摸的。我们发现，在棕色变色龙的背部图案（钻石/V形）的女性有限的多态性是由一个单一的孟德尔基因座控制。该基因座含有与雌激素受体-1基因相邻并共表达的基因CCDC 170，解释了为什么多态性是女性限制的。CCDC 170是细胞迁移能力的高尔基体微管网络的组织者，两个分离的等位基因编码结构不同的蛋白质。我们基于代理的皮肤发育建模表明，原则上，细胞迁移行为的变化足以在两种形态之间切换。这些结果表明，CCDC 170可能被选为颜色图案变体之间的开关，可能是通过调节细胞迁移行为。
Animal coloration is often expressed in periodic patterns that can arise from differential cell migration, yet how these processes are regulated remains elusive. We show that a female-limited polymorphism in dorsal patterning (diamond/chevron) in the brown anole is controlled by a single Mendelian locus. This locus contains the gene CCDC170 that is adjacent to, and coexpressed with, the Estrogen receptor-1 gene, explaining why the polymorphism is female limited. CCDC170 is an organizer of the Golgi-microtubule network underlying a cell's ability to migrate, and the two segregating alleles encode structurally different proteins. Our agent-based modeling of skin development demonstrates that, in principle, a change in cell migratory behaviors is sufficient to switch between the two morphs. These results suggest that CCDC170 might have been co-opted as a switch between color patterning morphs, likely by modulating cell migratory behaviors.