Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6:: A randomized, double-blind, placebo-controlled study
Aspirin, but not propranolol, attenuates the acute stress-induced increase in circulating levels of interleukin-6:: A randomized, double-blind, placebo-controlled study
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DOI：
10.1016/j.bbi.2007.07.005
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发表时间：
2008-02-01
影响因子：
15.1
通讯作者：
Fischer, Joachim E.
中科院分区：
文献类型：
--
作者：
von Kaenel, Roland;Kudielka, Brigitte M.;Fischer, Joachim E.
心理社会应激可能通过引起促炎细胞因子白细胞介素（IL）-6循环水平升高而增加动脉粥样硬化血栓事件的风险。我们研究了阿司匹林和普萘洛尔对急性心理社会应激时血浆IL-6水平反应性的影响。在5天内，64名健康受试者随机、双盲接受每日口服阿司匹林100 mg+长效普萘洛尔80 mg、阿司匹林100 mg+安慰剂、长效普萘洛尔80 mg+安慰剂或安慰剂+安慰剂。此后，所有受试者都接受了13分钟的特里尔社会压力测试，该测试包括准备阶段、工作面试和心算任务。在应激前和应激后即刻以及应激后45分钟和105分钟收集的血液样品中测量血浆IL-6水平。从应激前到应激后105分钟的IL-6变化在服用阿司匹林的受试者和未服用阿司匹林的受试者之间存在差异（p = 0：033; n（p）（2）= 0.059）。与未服用阿司匹林的受试者相比，服用阿司匹林的受试者的IL-6水平从应激前到应激后105分钟增加较少（p < 0.027），并且在应激后105分钟时更低（p = 0.010）。当控制性别、年龄、腰臀比、平均动脉血压和吸烟状况时，这些结果的显著性保持不变。普萘洛尔治疗与应激诱导的IL-6水平变化无显著相关性。此外，阿司匹林和普萘洛尔在确定IL-6应激反应方面没有显著的相互作用。阿司匹林而不是普萘洛尔减弱了应激诱导的血浆IL-6水平升高。这表明阿司匹林治疗可能降低急性精神压力引发的动脉粥样硬化血栓事件风险的一种机制。(C)2007年爱思唯尔公司All rights reserved.
Psychosocial stress might increase the risk of atherothrombotic events by setting off an elevation in circulating levels of the proinflammatory cytokine interleukin (IL)-6. We investigated the effect of aspirin and propranolol on the responsiveness of plasma IL-6 levels to acute psychosocial stress. For 5 days, 64 healthy subjects were randomized, double-blind, to daily oral aspirin 100 mg plus long-acting propranolol 80 mg, aspirin 100 mg plus placebo, long-acting propranolol 80 mg plus placebo; or placebo plus placebo. Thereafter, all subjects underwent the 13-min Trier Social Stress Test, which combines a preparation phase, a job interview, and a mental arithmetic task. Plasma IL-6 levels were measured in blood samples collected immediately pre- and post-stress, and 45 min and 105 min thereafter. The change in IL-6 from pre-stress to 105 min post-stress differed between subjects with aspirin medication and those without (p = 0:033; n(p)(2) = 0.059). IL-6 levels increased less from pre-stress to 105 min post-stress (p < 0.027) and were lower (p = 0.010) at 105 min post-stress in subjects with aspirin than in subjects without aspirin. The significance of these results was maintained when controlling for gender, age, waist-to-hip ratio, mean arterial blood pressure, and smoking status. Medication with propranolol was not significantly associated with the stress-induced change in IL-6 levels. Also, aspirin and propranolol did not significantly interact in determining the IL-6 stress response. Aspirin but not propranolol attenuated the stress-induced increase in plasma IL-6 levels. This suggests one mechanism by which aspirin treatment might reduce the risk of atherothrombotic events triggered by acute mental stress. (C) 2007 Elsevier Inc. All rights reserved.