The evidence for sweet substance-induced analgesia in adult human
The evidence for sweet substance-induced analgesia in adult human
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DOI：
10.11154/pain.23.159
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发表时间：
2008-01-01
期刊：
影响因子：
--
通讯作者：
Ishikawa, Toshizo
中科院分区：
文献类型：
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作者：
Kakeda, Takahiro;Ito, Misae;Ishikawa, Toshizo
背景：甜物质诱导的镇痛（SIA）在啮齿类动物中得到了广泛的研究。这种机制被认为与抗伤害过程中的中央调节系统有关，利用甜味而不是分散注意力。然而，在人类中，这种SIA仅限于新生儿。在成人中，对SIA对生长的影响降低的原因研究较少。因此，关于成人SIA的共识尚未获得。因此，我们旨在通过冷压试验确定蔗糖的甜味刺激对健康成人伤害感受的反应。方法：本研究采用交叉设计的随机对照。采用冷压试验（CPT）， 13名成年男性受试者将一只手浸入冷水中诱导伤害感受。受试者在CPT前和CPT期间将24%重量/体积的蔗糖溶液或蒸馏水含在口中。镇痛效果和情绪状态定量评估如下：痛阈；疼痛容忍度;疼痛强度;品味快乐;以及简短的日文心境状态量表（POMS）。结果：与蒸馏水对照组相比，含糖溶液组疼痛阈值明显升高（p< 0.05）。此外，蔗糖溶液的口感愉悦度显著高于蒸馏水（p< 0.05）。结论：这些数据清楚地表明，蔗糖的甜味刺激可诱导成人的抗痛觉，并与味觉愉悦相关，提示甜味物质诱导的镇痛可应用于年轻男性成人。
Background: Sweet substance-induced analgesia (SIA) has been widely investigated in rodents. The mechanism is thought to be involved in the central regulating systems in the anti-nociceptive process, taking advantage of sweet taste and not acting as a distraction. In human, this SIA is, however, limited in neonatal. The reasons underlying the reduced effects of SIA with growth have been less studied in adults. Consensus regarding SIA thus has not yet to be obtained in adults. Therefore, we aimed to determine the sweet stimulus of sucrose on responses of healthy adults to nociception using cold pressor testing.Methods: The present study was carried out a randomized control with crossover design. Using the cold pressor test (CPT), 13 adult male subjects immersed a hand in cold water to induce nociception. Subjects held either a 24% weight/volume sucrose solution or distilled water in their mouth before and during CPT. Analgesic effect and emotional state were quantitatively assessed as follows: pain threshold; pain tolerance; pain intensity; taste pleasantness; and the brief Japanese version of the Profile of Mood State (POMS).Results: With subjects held sucrose solution in the mouth, pain threshold was increased significantly (p< 0.05) when compared with distilled water. In addition, the taste pleasantness rating was significantly higher with sucrose solution than that with distilled water (p< 0.05).Conclusions: These data clearly indicate that the sweet stimulus of sucrose induces antinociception associated with taste pleasantness in adults, suggesting sweet substance-induced analgesia can be applied to young male adults.