WNT as a Driver and Dependency in Cancer.
WNT as a Driver and Dependency in Cancer.
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WNT作为癌症的驱动力和依赖性。
DOI：
10.1158/2159-8290.cd-21-0190
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发表时间：
2021-10
期刊：
影响因子：
28.2
通讯作者：
Dow LE
中科院分区：
文献类型：
--
作者：
Parsons MJ;Tammela T;Dow LE
WNT信号通路是发育和成人组织稳态的关键调节剂，并且在许多癌症类型中变得失调。虽然WNT信号传导的过度激活很常见，但遗传WNT通路改变的类型和频率在不同癌症之间可能会有很大差异，这突出了WNT驱动疾病的可能癌症特异性机制。在这篇综述中，我们讨论了WNT通路中断如何有助于不同器官的肿瘤发生，以及WNT如何影响肿瘤细胞和免疫微环境。最后，我们描述了最近和正在进行的努力，目标致癌WNT信号作为一种治疗策略。
The WNT signaling pathway is a critical regulator of development and adult tissue homeostasis and becomes dysregulated in many cancer types. While hyperactivation of WNT signaling is common, the type and frequency of genetic WNT pathway alterations can vary dramatically between different cancers, highlighting possible cancer-specific mechanisms for WNT-driven disease. In this review, we discuss how WNT pathway disruption contributes to tumorigenesis in different organs and how WNT impacts the tumor cell and immune microenvironment. Finally, we describe recent and ongoing efforts to target oncogenic WNT signaling as a therapeutic strategy.