Randomized controlled evaluation of the effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects
Randomized controlled evaluation of the effects of cognitive-behavioral stress management on cortisol responses to acute stress in healthy subjects
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DOI：
10.1016/s0306-4530(02)00069-0
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发表时间：
2003-08-01
影响因子：
3.7
通讯作者：
Ehlert, U
中科院分区：
文献类型：
--
作者：
Gaab, J;Blättler, N;Ehlert, U
心理应激是下丘脑-垂体-肾上腺(HPA)轴的有效激活剂，而神经内分泌应激反应是维持体内平衡所必需的，有证据表明HPA轴的过度激活构成了疾病和精神病理的风险。本研究的目的是评估认知行为压力管理训练对健康青年在急性心理社会压力下的内分泌应激反应和认知评估的影响。研究对象为48名健康、不吸烟、自述无急慢性精神疾病的男性学生，随机分为两组，分别在标准化心理社会压力测试(Trier Social Stress Test，TSST)前后接受基于团体的认知-行为压力管理训练。通过唾液游离皮质醇反应和对TSST的认知评估过程来评估内分泌和心理应激反应。与对照组相比，治疗组内分泌反应减弱(F(2.5 5/117.41)=3.81；P=0.0 2：效应大小f(2)=0.35)。此外，与对照组相比，SIT组受试者具有较低的压力评估和较高的控制期望(F(2/45)=6.56；P=0.003，效应量f(2)=0.29)。短期基于群体的认知-行为压力管理训练降低了健康受试者对急性应激源的神经内分泌应激反应。因此，压力管理培训可能有助于预防压力引起的神经内分泌激活的有害影响(C)2003爱思唯尔科学有限公司。保留所有权利。
Psychosocial stress is a potent activator of the hypothalamus-pituitary-adrenal (HPA) axis, While neuroendocrine stress responses are essential for the maintenance of homeostasis, evidence suggests that excessive activation of the HPA axis constitutes a risk for disease and psychopathology. The purpose of the present study was to assess the effect of cognitive-behavioral stress management training on endocrine stress responses and cognitive appraisal under acute psychosocial stress among healthy young subjects. Forty-eight healthy, non-smoking male Students without acute or chronic medical or psychiatric disorder on self report were randomly assigned to receive group-based cognitive-behavioral stress management training either before or after a standardized psychosocial stress test (Trier Social Stress Test, TSST). Endocrine and psychological stress responses were assessed with salivary free cortisol response and cognitive appraisal processes to the TSST. In comparison with the control group, subjects in the treatment Group showed an attenuated endocrine response (F (2.55/117.41) = 3.81; P = 0.02: effect size f(2) = 0.35) to the TSST. In addition, subjects in the SIT group had lower stress appraisal and higher control expectancies (F (2/45) = 6.56; P = 0.003, effect size f(2) = 0.29) compared to controls. Short group-based cognitive-behavioral stress management training reduces the neuroendocrine stress response to an acute stressor in healthy subjects. Therefore, stress management training may prove useful in preventing detrimental effects of stress-induced neuroendocrine activation (C) 2003 Elsevier Science Ltd. All rights reserved.