Health-related quality of life predicts onset of asthma in a longitudinal population study
Health-related quality of life predicts onset of asthma in a longitudinal population study
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DOI：
10.1016/j.rmed.2008.09.015
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发表时间：
2009-02-01
影响因子：
4.3
通讯作者：
Rask-Andersen, Anna
中科院分区：
文献类型：
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作者：
Leander, Mai;Cronqvist, Agneta;Rask-Andersen, Anna
背景：健康相关生活质量（HRQL）已越来越多地被用作哮喘的结果测量，但对低健康相关生活质量的预后含义知之甚少。本研究的目的是调查一组生活质量指标是否可以预测哮喘的发作。方法：在基线研究中，391名无哮喘的受试者在1990年回答了呼吸问卷和哥德堡生活质量（GQL）量表。GQL问卷包括两个部分：(1)hrql相关症状的患病率和(2)身体、心理和社会维度的幸福感得分。研究人员还对参与者进行了肺量测定和过敏测试。2003年，与1990年使用的呼吸系统问卷相同。有290名应答者，其中22名受试者患有哮喘。结果：随访时发生哮喘的参与者比未发生哮喘的参与者在基线时具有更高的严重紊乱（30%对10%）、胸痛问题（16%对2%）、抑郁（40%对20%）、放松困难（40%对13%）和便秘（25%对2%）的患病率（p < 0.05）。患有哮喘的受试者在健康变量上的得分也明显较低，这些变量包括坡度、能量、情绪、耐心、记忆力、食欲、健康和在家外的欣赏感。在调整了年龄、性别、吸烟习惯、哮喘遗传、社会经济群体和建筑湿度后，这些差异仍然存在。结论：基线健康相关生活质量较低的参与者更有可能在12年后报告患上哮喘。(C) 2008 Elsevier Ltd版权所有。
Background: Health-related quality of life (HRQL) has been increasingly used as an outcome measure in asthma, but less is known about the prognostic implication of low health-related quality of life. The purpose of this study was to investigate if a set of quality of life measures could predict onset of asthma.Methods: In the baseline study 391 subjects without asthma answered a respiratory questionnaire and the Gothenburg Quality of Life (GQL) instrument in 1990. The GQL questionnaire included two parts: (1) the prevalence of HRQL-related symptoms and (2) well-being scores for physical, mental and social dimensions. The participants were also investigated with spirometry and allergy testing. In 2003, the same respiratory questionnaire that had been used in 1990 was sent. There were 290 responders, of whom 22 subjects had developed asthma.Results: Participants who had developed asthma by the follow-up had a higher prevalence of steep disturbances (30% vs. 10%), problems with chest pain (16% vs. 2%), depression (40% vs. 20%) difficulty relaxing (40% vs. 13%) and constipation (25% vs. 2%) at baseline than participants who did not develop asthma (p < 0.05). Subjects who developed asthma also scored significantly lower on well-being variables as steep, energy, mood, patience, memory, appetite, fitness and sense of appreciation outside home. These differences remained after adjusting for age, sex, smoking habits, asthma heredity, socioeconomic groups and building dampness.Conclusion: Participants with low health-related quality of life at baseline were more likely to report having developed asthma 12 years later. (C) 2008 Elsevier Ltd. All rights reserved.