Pulmonary surfactant: an interdisciplinary approach.
Pulmonary surfactant: an interdisciplinary approach.
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肺表面活性物质：一种跨学科的方法。
DOI：
10.1152/jappl.1984.57.6.1613
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
Finkelstein,JN
中科院分区：
文献类型：
--
作者：
Notter,RH;Finkelstein,JN
肺表面活性物质的研究是从基于从生物物理和物理化学、生物化学、细胞生物学、生理学和医学获得的信息的跨学科相关性的角度来考虑的。描述了肺表面活性物质系统的重要分子组成的最新观点，并与对呼吸生理学产生适当影响所必需的生物物理表面性质有关。贯穿始终强调肺表面活性物质多学科特征的基本重要性，以及这些描述之间的相关性。这种方法的主要优点是它提供了广泛但协调的原则和数据，用来检验肺表面活性物质在呼吸生理学和病理生理学中的功能和作用的假说。这一观点被用来检查有关肺表面活性物质的功能组成、其在生理温度和湿度下降低表面张力的特性，以及与在治疗表面活性物质缺乏状态中形成有效的外源表面活性混合物有关的考虑因素。还讨论了肺表面活性物质在肺泡水平的体内生物物理状态，包括对肺泡期的最新认识，以及功能表面活性物质作用于正常肺以干燥的肺泡为主的概念。
Pulmonary surfactant research is considered from the perspective of interdisciplinary correlations based on information acquired from biophysics and physical chemistry, biochemistry, cell biology, physiology, and medicine. Current views of the important molecular constituents of the pulmonary surfactant system are described and related to the biophysical surface properties necessary to generate appropriate effects on respiratory physiology. The fundamental importance of multidisciplinary characterizations of lung surfactant, together with correlations between these descriptions, is stressed throughout. The primary advantage of such an approach is that it provides broad but coordinated principles and data with which to test hypotheses of lung surfactant function and roles in respiratory physiology and pathophysiology. This perspective is used to examine available information about the functional composition of lung surfactant, its surface tension-lowering properties at physiological temperature and humidity, and considerations relevant to the formulation of effective exogenous surface-active mixtures in the treatment of surfactant-deficient states. Also discussed is the biophysical state in vivo of pulmonary surfactant at the alveolar level, including current knowledge of the alveolar hypophase as well as the concept of functional surfactant acting in predominantly dry alveoli in the normal lung.