A prospective analysis interstitial pneumonia and opportunistic viral infection among recipients of allogeneic bone marrow grafts.
A prospective analysis interstitial pneumonia and opportunistic viral infection among recipients of allogeneic bone marrow grafts.
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同种异体骨髓移植受者间质性肺炎和机会性病毒感染的前瞻性分析。
DOI：
10.1093/infdis/136.6.754
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发表时间：
1977
期刊：
影响因子：
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通讯作者：
E. Thomas
中科院分区：
文献类型：
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作者：
P. Neiman;W. Reeves;G. Ray;N. Flournoy;Lerner Kg;G. Sale;E. Thomas
对80例急性白血病和再生障碍性贫血的骨髓移植受者进行了系列病毒培养、巨细胞病毒(CMV)补体结合抗体测定以及肺活检和尸检资料的前瞻性研究。有43例间质性肺炎，其中28例死亡。约40%的病例是特发性的。CMV是最常见的候选病原体，存在于47%的受累肺中。移植后平均53天，46%的受者从某些部位脱落巨细胞病毒。在移植前CMV抗体滴度阳性的受者中，这一事件的发生率是血清阴性受者的三倍。对巨细胞病毒感染无明显反应明显增加了间质性肺炎死亡的风险。移植物抗宿主病显著增加间质性肺炎的发生率和致死率。白血病(而不是再生障碍性贫血)的存在和/或植入准备技术中的某些因素可能是重要的。
A prospective study of 80 bone marrow transplant recipients with acute leukemia and aplastic anemia employed serial viral cultures, determination of complement-fixing antibody to cytomegalovirus (CMV), and study of material obtained from open lung biopsy and autopsy. There were 43 episodes of interstitial pneumonia, 28 of which were fatal. About 40% of the cases were idiopathic. CMV was the most common candidate pathogen, present in 47% of affected lungs. By a median of 53 days following transplantation, 46% of the recipients were shedding CMV from some site. This event was three times more frequent among recipients who had positive titers of antibody to CMV before transplantation than among seronegative recipients. Failure to respond werologically to CMV infection markedly increased the hazard of dying of interstitial pneumonia. Graft-vs-host disease significantly increased the incidence and lethality of interstitial pneumonia. The presence of leukemia (rather than aplastic anemia) and/or certain factors in the technique of preparation for engraftment may have been significant.
DOI：
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发表时间：
1972
期刊：
--
影响因子：
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作者：
D. Cox
通讯作者：
D. Cox