The ubiquitin-proteasome system regulates plant hormone signaling.
The ubiquitin-proteasome system regulates plant hormone signaling.
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DOI：
10.1111/j.1365-313x.2010.04112.x
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发表时间：
2010-03
期刊：
影响因子：
--
通讯作者：
Estelle M
中科院分区：
文献类型：
--
作者：
Santner A;Estelle M
植物利用泛素-蛋白酶体系统（UPS）来调节生长发育的几乎每一个方面。泛素通过E1、E2和E3三种酶的作用与靶蛋白共价结合。这种翻译后修饰的最终结果取决于泛素连锁的性质和多泛素化的程度。在大多数情况下，泛素化导致26S蛋白酶体中靶蛋白的降解。在过去的10年里，UPS在激素生物学中发挥着重要的调节作用已经变得很清楚。特别是E3泛素连接酶积极参与激素感知、激素信号通路的去抑制、激素特异性转录因子的降解和激素生物合成的调节。可以肯定的是，随着植物中近1200种潜在的E3s的更多被阐明，将会发现更多的功能。
Plants utilize the ubiquitin-proteasome system (UPS) to modulate nearly every aspect of growth and development. Ubiquitin is covalently attached to target proteins through the action of three enzymes known as E1, E2, and E3. The ultimate outcome of this post-translational modification depends on the nature of the ubiquitin linkage and the extent of polyubiquitination. In most cases, ubiquitination results in degradation of the target protein in the 26S proteasome. During the last 10 years it has become clear that the UPS plays a prominent regulatory role in hormone biology. E3 ubiquitin ligases in particular actively participate in hormone perception, de-repression of hormone signaling pathways, degradation of hormone specific transcription factors, and regulation of hormone biosynthesis. It is certain that additional functions will be discovered as more of the nearly 1200 potential E3s in plants are elucidated.