Midline signals regulate retinal neurogenesis in zebrafish
Midline signals regulate retinal neurogenesis in zebrafish
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DOI：
10.1016/s0896-6273(00)00034-9
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发表时间：
2000-08-01
期刊：
影响因子：
16.2
通讯作者：
Wilson, SW
中科院分区：
文献类型：
--
作者：
Masai, I;Stemple, DL;Wilson, SW
在斑马鱼中，神经元分化在视网膜上的进展模式与果蝇发育中的眼睛中扫过的神经源性波相似。我们发现斑马鱼的一种与果蝇同系物ath5的表达扫过眼睛，预测神经元分化的波。通过分析ath5的表达调控，我们阐明了视网膜神经发生发生和扩散的调控机制。在缺少轴向组织（包括脊索前板）的结通路突变胚胎中，ath5表达缺失。轴向组织可能的作用是诱导视柄细胞随后调节ath5的表达。我们的研究结果表明，从脊索前板开始，从视柄开始的一系列诱导事件调节了神经元分化在斑马鱼视网膜上的传播。
In zebrafish, neuronal differentiation progresses across the retina in a pattern that is reminiscent of the neurogenic wave that sweeps across the developing eye in Drosophila. We show that expression of a zebrafish homolog of Drosophila atonal, ath5, sweeps across the eye predicting the wave of neuronal differentiation. By analyzing the regulation of ath5 expression, we have elucidated the mechanisms that regulate initiation and spread of neurogenesis in the retina. ath5 expression is lost in Nodal pathway mutant embryos lacking axial tissues that include the prechordal plate. A likely role for axial tissue is to induce optic stalk cells that subsequently regulate ath5 expression. Our results suggest that a series of inductive events, initiated from the prechordal plate and progressing from the optic stalks, regulates the spread of neuronal differentiation across the zebrafish retina.