Pathophysiological characteristics of labile hypertensive patients determined by the cold pressor test.
Pathophysiological characteristics of labile hypertensive patients determined by the cold pressor test.
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通过冷加压试验确定不稳定高血压患者的病理生理特征。
DOI：
10.1253/jcj.44.438
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发表时间：
1980
期刊：
影响因子：
--
通讯作者：
T. Kokubu
中科院分区：
文献类型：
--
作者：
E. Murakami;K. Hiwada;T. Kokubu
本文观察了I型不稳定(青少年不稳定)高血压患者、II型不稳定(中年不稳定)高血压患者、既往高血压患者和正常人在冷加压试验中的血流动力学变化。在正常、I型不稳定高血压和确诊高血压受试者中，测试期间的升压反应主要是由于外周阻力的增加。在II型不稳定高血压患者中，冷刺激期间血压升高伴随着心输出量的增加。因此，就试验期间的血流动力学变化而言，II型不稳定高血压明显区别于其他类型的高血压。然而，在II型不稳定高血压患者中，安定减少了试验期间心输出量的增加，导致了与正常受试者相似的血流动力学变化。阿托品化后，在冷加压试验中，I型和既往高血压患者的血流动力学模式与II型不稳定患者相似。结论：冷刺激引起的心输出量过大是II型不稳定性高血压患者的一个明显的血流动力学特征，这种明显的血流动力学特征可能与副交感神经张力降低有关。
Hemodynamic changes during the cold pressor test were examined in Type I labile (juvenile labile) hypertensive patients, Type II labile (middle aged labile) hypertensive patients, established hypertensive patients and normal subjects. In normal, Type I labile hypertensive and established hypertensive subjects, the pressor response during the test was accounted for chiefly by a rise in peripheral resistance. In Type II labile hypertensive patients, an increase in blood pressure during cold stimuli was accompanied by an augmented cardiac output. Therefore, Type II labile hypertension is separated clearly from other types of hypertension with respect to hemodynamic changes during the test. In Type II labile hypertensive patients, however, diazepam reduced an increase in cardiac output during the test, resulting in hemodynamic changes similar to those of normal subjects. After atropinization, the hemodynamic pattern of Type I and established hypertensives changed similar to that of Type II labile patients during the cold pressor test. It is concluded that an excessive cardiac output caused by the cold stimuli is a distinctive hemodynamic characteristics of Type II labile hypertensive patients, and this distinctive hemodynamic characteristics might be due to the decreased parasympathetic tone.