3-ACETYLPYRIDINE - EFFECTS IN VITRO RELATED TO TERATOGENIC ACTIVITY IN CHICKEN EMBRYOS
3-ACETYLPYRIDINE - EFFECTS IN VITRO RELATED TO TERATOGENIC ACTIVITY IN CHICKEN EMBRYOS
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DOI：
10.1126/science.160.3831.1009
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发表时间：
1968-01-01
期刊：
影响因子：
56.9
通讯作者：
KAPLAN, NO
中科院分区：
文献类型：
--
作者：
CAPLAN, AI;ZWILLING, E;KAPLAN, NO
在发育中的鸡胚胎中，3-乙酰吡啶可导致骨骼肌发育不全，而烟酰胺可完全逆转骨骼肌发育不全。发育中的鸡胚肌肉培养物表现出 3-乙酰吡啶产生的退化效应；烟酰胺可以逆转这些影响。 3-乙酰吡啶可增强培养的软骨形成细胞中的软骨生成；这种增强作用可以被烟酰胺完全逆转。有人认为烟酰胺或吡啶核苷酸依赖性反应通过抑制软骨形成细胞和增强肌肉细胞表达或增殖来影响肢体中胚层细胞的正常分化。
Production of skeletal muscle hypoplasia by 3-acetylpyridine and its complete reversal by nicotinamide in developing chicken embryos have been confirmed. Cultures of developing embryonic chicken muscle show degenerative effects produced by 3-acetylpyridine; these effects are reversed by nicotinamide. Cartilage production in cultured chondrogenic cells is potentiated by 3-acetylpyridine; this potentiation is completely reversed by nicotinamide. It is suggested that nicotinamide- or pyridine-nucleotide-dependent reactions influence normal differentiation of limb mesoderm cells by inhibiting chondrogenic-cell and potentiating muscle-cell expression or proliferation.