Control of repetitive lip and finger movements in parkinson's disease: Influence of external timing signals and simultaneous execution on motor performance
Control of repetitive lip and finger movements in parkinson's disease: Influence of external timing signals and simultaneous execution on motor performance
复制标题
帕金森病患者嘴唇和手指重复运动的控制：外部定时信号和同时执行对运动性能的影响
DOI：
10.1002/mds.870120507
复制
发表时间：
1997
影响因子：
8.6
通讯作者：
J. Dichgans
中科院分区：
文献类型：
--
作者：
J. Konczak;H. Ackermann;I. Hertrich;S. Spieker;J. Dichgans
这项研究解决了外部定时信号和/或其他肢体的同步节律运动是否可以减轻与帕金森病（PD）相关的运动缺陷的问题。受试者同时或单独进行有节奏的嘴唇和手指运动。此外，他们必须自我调整自己的动作或将其与外部信号相匹配。我们的结果总结如下：(a) 12例患者中有7例具有足够的平均重复率；也就是说，它们在全球范围内完成了任务要求。其余5名患者有不同程度的加速反应，不能完全与外部起搏信号同步运动。(b) PD患者在手指轻敲时表现出低血量，但在唇部运动时没有。它们的运动并没有异常减慢，但峰值速度被适当地缩放，甚至降低了运动幅度。(c) PD组的平均重复率、频率响应稳定性和运动学在内外刺激条件下没有差异，但与对照组的表现不同。(d)在双任务执行过程中，运动学测量没有得到改善。PD患者不能在效应器之间保持1:1的节律。同时运动执行时加速的发生率增加。我们的结论是，使用外部起搏信号可能有助于PD患者的运动启动，但不能改善他们在产生重复性运动时的时间或空间协调。同时执行不一定能提高运动表现，但实际上可能对易于加速的患者有不利影响。
This study addresses the question of whether external timing signals and/or simultaneous rhythmic movements of other limbs can alleviate sequencing motor deficits associated with Parkinson's disease (PD). Subjects performed rhythmic lip and finger movements simultaneously or in isolation. In addition, they had to self‐pace their movements or match them to an external signal. Our results are summarized as follows: (a) Seven of 12 patients had adequate mean repetition rates; that is, they fulfilled the task requirements on a global scale. The remaining five patients had various degrees of hastened responses and were not fully able to synchronize their movements to an external pacing signal. (b) PD patients exhibited hypometria in their finger tapping, but not in their lip movements. Their movements were not abnormally slowed, but peakvelocity was appropriately scaled, even to reduced movement amplitudes. (c) Mean repetition rates, stability of frequency response, and kinematics did not differ between conditions of external and internal stimulation within the PD group, but were different from the control group performance. (d) Kinematic measures were not improved during dual‐task execution. PD patients were not able to maintain a 1:1 rhythm between effectors. The incidence of hastening increased during simultaneous motor execution. We conclude that the use of external pacing signals might aid movement initiation of PD patients, but does not improve their temporal or spatial coordination when generating repetitive movements. Simultaneous execution does not necessarily enhance motor performance, but might actually have detrimental effects in patients prone to hastening.