Assessing Membrane Protein Structural Dynamics within Lipid Nanodiscs.
Assessing Membrane Protein Structural Dynamics within Lipid Nanodiscs.
复制标题
评估脂质纳米圆盘内的膜蛋白结构动力学。
DOI：
10.1016/j.tibs.2019.08.003
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发表时间：
2019
影响因子：
13.8
通讯作者：
Reading E
中科院分区：
文献类型：
--
作者：
Reading E
膜蛋白的结构、动力学和功能与其所处的复杂多样的细胞脂膜有着密切的关系。脂质纳米盘技术提供了一种具有可溶性脂质双层环境的膜蛋白，无论是通过在其天然脂质包围中直接提取（图1A），还是通过与分离的脂质重构（图1B），都可以进行各种体外研究。
Membrane protein structure, dynamics, and function have an intimate relationship with the complex and varied cellular lipid membranes they reside in. Lipid nanodisc technologies provide a membrane protein with a soluble lipid bilayer environment–either through direct extraction within their native lipid surround (Figure 1A) or though reconstitution with isolated lipids (Figure 1B)–amenable to a variety of in vitro investigations.