Adverse events following a third dose of measles, mumps, and rubella vaccine in a mumps outbreak
Adverse events following a third dose of measles, mumps, and rubella vaccine in a mumps outbreak
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DOI：
10.1016/j.vaccine.2012.09.053
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发表时间：
2012-11-19
期刊：
影响因子：
5.5
通讯作者：
Kutty, Preeta K.
中科院分区：
文献类型：
--
作者：
Abedi, Glen R.;Mutuc, Jeffry D.;Kutty, Preeta K.
在2009-2010年纽约州一个村庄爆发腮腺炎期间，作为一项控制措施，向三所学校的儿童接种了第三剂麻疹、腮腺炎和风疹（MMR）疫苗。通过对6-12年级所有儿童进行自我报告调查，收集局部和全身不良事件（AE）的信息。利用医生记录和疫苗不良事件报告系统（VAERS）对MMR疫苗接种后的AE进行了全面搜索。对1969年至2011年使用Jeryl-Lynn株的含腮腺炎疫苗相关AE的已发表报告进行文献检索。共有1755人接种了第三剂疫苗；1597人（91.0%）回复调查。其中，115例（7.2%）报告在接种疫苗后2周内至少发生一次局部或全身AE。最常见的AE是“注射部位疼痛、发红或肿胀”（3.6%）和“关节或肌肉疼痛”（1.8%）。调查、医生记录和VAERS均未报告严重AE。在本研究中发现的AE的比例低于或在先前的第一次和第二次MMR疫苗研究中报告的比例范围内。这项研究的结果表明，在爆发环境中接种第三剂MMR疫苗是安全的，注射部位反应比全身反应更频繁。然而，为了评估第三剂MMR疫苗后发生罕见或严重AE的风险，需要进行更长期的研究。(C) 2012 Elsevier Ltd.版权所有。
During a 2009-2010 mumps outbreak in a New York State village, a third dose of measles, mumps, and rubella (MMR) vaccine was administered to children in three schools as a control measure. Information on local and systemic adverse events (AE) was collected by a self-report survey distributed to all children in grades 6-12. A comprehensive search for AE following MMR vaccination was conducted using physician records and the Vaccine Adverse Events Reporting System (VAERS). A literature search was performed for published reports pertaining to AE associated with mumps-containing vaccine, using the Jeryl-Lynn strain, from 1969 to 2011. A total of 1755 individuals received the third dose; 1597 (91.0%) returned the survey. Of those, 115 (7.2%) reported at least one local or systemic AE in the 2 weeks following vaccination. The most commonly reported AE were "pain, redness, or swelling at the injection site" (3.6%) and "joint or muscle aches" (1.8%). No serious AE were reported in the survey, physician records or through VAERS. The proportions of AE found in the present study were lower than or within the range of those reported in prior studies of first- and second-dose MMR vaccine studies. The results of this study suggest that a third dose of MMR vaccine administered in an outbreak setting is safe, with injection site reactions reported more frequently than systemic reactions. However, to assess risk for rare or serious AE after a third dose of MMR vaccine, longer term studies would be required. (C) 2012 Elsevier Ltd. All rights reserved.