The Central Clock Neurons Regulate Lipid Storage in Drosophila
The Central Clock Neurons Regulate Lipid Storage in Drosophila
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DOI：
10.1371/journal.pone.0019921
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发表时间：
2011-05-18
期刊：
影响因子：
3.7
通讯作者：
Sehgal, Amita
中科院分区：
文献类型：
--
作者：
DiAngelo, Justin R.;Erion, Renske;Sehgal, Amita
脂质分解和合成的适当平衡对于实现能量稳态至关重要，因为这两个过程中的任何一个的改变都可能导致肥胖等病理状态。脂质代谢的调节相当复杂，需要集成多个信号来控制代谢组织中的总体甘油三酯水平。基于证明生物钟对新陈代谢影响的研究，我们试图确定果蝇大脑中的中央时钟细胞是否有助于脂肪体（果蝇的主要营养储存器官）中的脂质水平。在这里，我们发现改变果蝇中央时钟神经元的功能会导致脂肪体甘油三酯的增加。我们还表明，尽管甘油三酯水平不受年龄影响，但它们会因中央时钟神经元中淀粉样蛋白的表达而增加。对脂质储存的影响似乎与生物钟输出无关，因为在导致运动节律改变的基因操作中并不总是观察到甘油三酯的变化。这些数据表明，中央时钟神经元的活动对于适当的脂质储存是必要的。
A proper balance of lipid breakdown and synthesis is essential for achieving energy homeostasis as alterations in either of these processes can lead to pathological states such as obesity. The regulation of lipid metabolism is quite complex with multiple signals integrated to control overall triglyceride levels in metabolic tissues. Based upon studies demonstrating effects of the circadian clock on metabolism, we sought to determine if the central clock cells in the Drosophila brain contribute to lipid levels in the fat body, the main nutrient storage organ of the fly. Here, we show that altering the function of the Drosophila central clock neurons leads to an increase in fat body triglycerides. We also show that although triglyceride levels are not affected by age, they are increased by expression of the amyloid-beta protein in central clock neurons. The effect on lipid storage seems to be independent of circadian clock output as changes in triglycerides are not always observed in genetic manipulations that result in altered locomotor rhythms. These data demonstrate that the activity of the central clock neurons is necessary for proper lipid storage.