Association of Serum Pyridoxal-5'-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study.
Association of Serum Pyridoxal-5'-Phosphate, Pyridoxal, and PAr with Colorectal Cancer Risk: A Large-Scale Case-Control Study.
复制标题
作者：
以前的流行病学研究集中在饮食维生素B6或循环吡哆醛-5 ′-磷酸（PLP）与结直肠癌风险的关联。本研究旨在研究维生素B6与结直肠癌风险的关系，结合PLP、吡哆醛（PL）加PLP和PAr（4-吡哆酸与PLP和PL之和的比值）的生物标志物。在中国广东省进行了一项大规模的以医院为基础的病例对照研究，其中包括1233例结直肠癌病例和1245例性别和年龄频率匹配的对照。采用超高效液相色谱-串联质谱法检测血清PLP、PL和4-吡哆酸（PA）。使用非条件logistic回归模型评估比值比（OR）和95%置信区间（95% CI）。血清PLP、PLP与PL之和与结直肠癌风险呈负相关，而PAr与结直肠癌风险呈正相关。比较最高和最低四分位数，血清PLP的校正OR（95% CI）为0.26（0.20-0.33，P趋势< 0.001），血清PLP + PL为0.51（0.40-0.66，P趋势< 0.001），PAr为2.90（2.25-3.75，P趋势< 0.001）。在男性组和吸烟组中，血清PLP和PAr与结直肠癌风险有显著更强的相关性。我们的研究结果支持维生素B6在中国人结直肠癌风险中的保护作用。PAr与结直肠癌风险的正相关表明炎症和氧化应激在结直肠癌发生中的潜在作用。
Previous epidemiological studies have focused on the association of dietary vitamin B6 or circulating pyridoxal-5′-phosphate (PLP) with colorectal cancer risk. This study aimed to investigate the vitamin B6 in relation to colorectal cancer risk combining the biomarkers of PLP, pyridoxal (PL) plus PLP, and PAr (the ratio of 4-pyridoxic acid over the sum of PLP and PL). A large-scale hospital-based case-control study was conducted in Guangdong Province, China, which included 1233 colorectal cancer cases and 1245 sex and age frequency-matched controls. Serum PLP, PL, and 4-pyridoxic acid (PA) were detected with ultra-high-performance liquid chromatography–tandem mass spectrometry. Unconditional logistic regression models were used to assess the odds ratios (ORs) and 95% confidence intervals (95% CIs). Serum PLP and the sum of PLP and PL were inversely associated with colorectal cancer risk, while PAr was positively associated with colorectal cancer risk. Comparing the highest with the lowest quartile, the adjusted OR (95% CI) was 0.26 (0.20–0.33, Ptrend < 0.001) for serum PLP, 0.51 (0.40–0.66, Ptrend < 0.001) for serum PLP plus PL, and 2.90 (2.25–3.75, Ptrend < 0.001) for PAr. Serum PLP and PAr had significantly stronger associations with colorectal cancer risk in the male group and smoking group. Our results supported the protective role of vitamin B6 in colorectal cancer risk among Chinese people. The positive association of PAr with colorectal cancer risk suggested the potential role of inflammation and oxidative stress in colorectal carcinogenesis.