An association between type 1 diabetes and idiopathic generalized epilepsy
An association between type 1 diabetes and idiopathic generalized epilepsy
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DOI：
10.1002/ana.20727
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发表时间：
2006-01-01
影响因子：
11.2
通讯作者：
Chadwick, DW
中科院分区：
文献类型：
--
作者：
McCorry, D;Nicolson, A;Chadwick, DW
目的：特发性全身性癫痫（IGEs）约占所有癫痫患者的30%。IGE和I型糖尿病（T1 D）都是严重的全球性问题，因为相关的医疗和社会管理成本。临床经验表明，这两种情况在个体中的出现频率比偶然预期的要高。方法：我们将15- 30岁人群中T1 D的人群患病率与518名15- 30岁IGE患者的队列进行比较。结果：我们发现IGE队列中的T1 D非常显著过量，比值比为4.4（95%置信区间，2.1-9.2）。解释我们的研究结果表明，T1 D的患病率在IGE的年轻人中增加了4倍。据我们所知，这是第一次发表的两种疾病之间的关联，并扩大了已知与T1 D相关的疾病。
Objective: Idiopathic generalized epilepsies (IGEs) account for approximately 30% of all patients with epilepsy. Both the IGEs and type I diabetes mellitus (T1D) represent serious worldwide problems, because of related medical and social management costs. Clinical experience suggested the two conditions were seen in individuals more frequently than might be expected by chance. Methods: We compared the population prevalence of T1D in 15- to 30-year-olds to a cohort of 518 15- to 30-year-olds with IGE. Results: We found a highly significant excess of T1D in our IGE cohort, with an odds ratio of 4.4 (95% confidence interval, 2.1-9.2). Interpretation Our results suggest that the prevalence of T1D is increased by a factor of four in young adults with IGE. To our knowledge, this is the first published association between the two conditions and expands the diseases known to be associated with T1D.