Expression and prognostic significance of angiopoietin in colorectal carcinoma
Expression and prognostic significance of angiopoietin in colorectal carcinoma
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DOI：
10.1002/jso.20423
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发表时间：
2006-12-01
影响因子：
2.5
通讯作者：
Hseu, Tzong-Hsiung
中科院分区：
文献类型：
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作者：
Chung, Yuan-Chang;Hou, Yung-Chi;Hseu, Tzong-Hsiung
背景与目的：恶性肿瘤的生长和转移依赖于血管生成。本研究旨在探讨促血管生成素-1（Angiopoietin-1，Ang-1）和促血管生成素-2（Angiopoietin-2，Ang-2）在进展期结直肠癌中的表达及其与预后的关系。采用免疫组化法检测肿瘤组织中Ang-1、Ang-2的表达，并分析其与临床病理因素及预后的关系。结果：在101例胃癌中，Ang-1和Ang-2阳性表达分别为26例（25.7%）和45例（44.6%）。Ang-1的高表达与高MVD相关。Ang-2过表达与淋巴结转移、静脉浸润、术前癌胚抗原水平及高MVD相关（P < 0.05）。Ang-1表达不显著上调MVD，而Ang-2表达显著上调MVD（P
Background and Objectives: Growth and metastasis of malignant tumors depend on the angiogenesis. The aim of this study was to elucidate the prognostic significance of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) expression in advanced colorectal carcinoma.Methods: Totally, 101 patients with surgically resected advanced colorectal carcinomas were enrolled. The tumor expressions of Ang-1 and Ang-2 were evaluated immunohistochemically, and their relationships with clinicopathological factors and prognosis were investigated. Tumor microvessel density (MVD) was also calculated and correlated with angiopoietin expression.Results: Ang-1 and Ang-2 were detected in 26 (25.7%) and 45 (44.6%), respectively, of 101 cancerous lesions. Overexpression of Ang-1 was correlated with high MVD. Overexpression of Ang-2 was correlated with lymph node metastasis, venous invasion, preoperative carcinoembryonic antigen levels, and high MVD (P < 0.05). MVD was not significantly upregulated by Ang-1 expression, but was significantly upregulated by Ang-2 expression (P