CONFORMATIONAL ASPECTS OF POLYPEPTIDE STRUCTURE .4. CRYSTAL-STRUCTURE OF S-THIAZOLIDINE-4-CARBOXYLIC ACID AND HELICAL STRUCTURE OF POLY[(S)-THIAZOLIDINE-4-CARBOXYLIC ACID]
CONFORMATIONAL ASPECTS OF POLYPEPTIDE STRUCTURE .4. CRYSTAL-STRUCTURE OF S-THIAZOLIDINE-4-CARBOXYLIC ACID AND HELICAL STRUCTURE OF POLY[(S)-THIAZOLIDINE-4-CARBOXYLIC ACID]
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DOI：
10.1002/bip.1972.360110903
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发表时间：
1972-01-01
期刊：
影响因子：
2.9
通讯作者：
CORRADINI, P
中科院分区：
文献类型：
--
作者：
GOODMAN, M;BENEDETTI, E;CORRADINI, P
通过使用 L-硫代脯氨酸的 X 射线衍射分析建立的新的键角和键长组，重新确定了顺式和变换式聚[(S)-噻唑烷-4-羧酸]的螺旋结构。还重复计算了聚-L-脯氨酸和聚[(S)-恶唑烷-4-羧酸]的螺旋结构。这些能量计算的结果表明，与聚-L-脯氨酸和聚[(S)-恶唑烷-4-羧酸]相比，聚[(S)-噻唑烷-4-羧酸]不应从反式变旋为顺式。这一结果是由于转换的能垒很可能太高造成的。之前的实验工作与这一发现是一致的。
The helical structures of poly[(S)‐thiazolidine‐4‐carboxylic acid], in thecisandtransforms, were redetermined by using the new sets of bond angles and bond lengths established by X‐ray diffraction analysis ofL‐thioproline. Calculations of the helical structures of poly‐L‐proline and poly[(S)‐oxazolidine‐4‐carboxylic acid] were also repeated. As a result of these energy calculations, it is suggested that, in contrast to poly‐L‐proline and poly[(S)‐oxazolidine‐4‐carboxylic acid], poly[(S)‐thiazolidine‐4‐carboxylic acid] should not mutarotate from thetransto thecisform. This result is due to the fact that the energy barrier for the conversion is most likely too high. Previous experimental work is consistent with this finding.