[(18) F]AV-1451 tau-PET and primary progressive aphasia.
[(18) F]AV-1451 tau-PET and primary progressive aphasia.
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DOI：
10.1002/ana.25183
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发表时间：
2018-03
影响因子：
11.2
通讯作者：
Whitwell JL
中科院分区：
文献类型：
--
作者：
Josephs KA;Martin PR;Botha H;Schwarz CG;Duffy JR;Clark HM;Machulda MM;Graff-Radford J;Weigand SD;Senjem ML;Utianski RL;Drubach DA;Boeve BF;Jones DT;Knopman DS;Petersen RC;Jack CR Jr;Lowe VJ;Whitwell JL
旨在评估原发性进行性失语 (PPA) 变体（语言缺乏、语义和语法）的 [18F]AV-1451 tau-PET 摄取模式，检查独立于临床诊断的 [18F]AV-1451 的区域摄取模式，并比较 [18F]AV-1451、[18F]-氟脱氧葡萄糖 (FDG)-PET 和 MRI 的诊断效用以区分 PPA 变体。我们对 40 名 PPA 患者（语词减少-PPA=14、语义-PPA=13 和语法-PPA=13）进行了 [18F]AV-1451 的统计参数映射，与 80 名认知正常、PiB 阴性对照（年龄和性别匹配 2:1）进行比较。对区域 [18F]AV-1451 tau-PET SUVR 进行主成分分析，以了解独立于临床诊断的 [18F]AV-1451 摄取的基本模式。利用惩罚多项式回归分析来评估诊断效用。与对照组、语义 PPA 和非语法 PPA 相比，Logopenic-PPA 在整个新皮质（尤其是颞顶叶）中表现出显着的吸收。语义-PPA和非语法-PPA显示局灶性[18F]AV-1451摄取的较温和模式。与对照和无语法-PPA 相比，语义-PPA 显示前内侧颞叶的摄取升高（左>右）。与对照组和语义 PPA 相比，无语法 PPA 在整个前额白质和皮质下灰质结构中显示出较高的摄取量（左>右）。区域[18F]AV-1451的主成分分析表明了两个主要维度，一个是区分语词减少-PPA与非语法-PPA和语义-PPA的严重性维度，以及区分非语法-PPA和语义-PPA案例的额叶与颞叶对比。 [18F]AV-1451的诊断效用优于MRI并且至少等于FDG-PET。 [18F]AV-1451 结合特征在 PPA 变体之间有所不同，并且在区分变体方面非常出色。 [18F]AV-1451 结合特性与临床实践中使用的其他脑成像方式一样好或更好，表明 [18F]AV-1451 可能在 PPA 中具有临床诊断效用。
To assess [18F]AV-1451 tau-PET uptake patterns across the primary progressive aphasia (PPA) variants (logopenic, semantic and agrammatic), examine regional uptake patterns of [18F]AV-1451 independent of clinical diagnosis, and compare the diagnostic utility of [18F]AV-1451, [18F]-fluorodeoxygluclose (FDG)-PET and MRI to differentiate the PPA variants. We performed statistical parametric mapping of [18F]AV-1451 across 40 PPA patients (logopenic-PPA=14, semantic-PPA=13 and agrammatic-PPA=13) compared to 80 cognitively normal, PiB-negative controls, age and gender matched 2:1. Principal component analysis of regional [18F]AV-1451 tau-PET SUVR was performed to understand underlying patterns of [18F]AV-1451 uptake independent of clinical diagnosis. Penalized multinomial regression analyses were utilized to assess diagnostic utility. Logopenic-PPA showed striking uptake throughout neocortex, particularly temporoparietal, compared to controls, semantic-PPA and agrammatic-PPA. Semantic-PPA and agrammatic-PPA showed milder patterns of focal [18F]AV-1451 uptake. Semantic-PPA showed elevated uptake (left>right) in anteromedial temporal lobes, compared to controls and agrammatic-PPA. Agrammatic-PPA showed elevated uptake (left>right) throughout prefrontal white matter and in subcortical grey matter structures, compared to controls and semantic-PPA. The principal component analysis of regional [18F]AV-1451 indicated two primary dimensions, a severity dimension that distinguished logopenic-PPA from agrammatic-PPA and semantic-PPA, and a frontal-versus-temporal contrast that distinguishes agrammatic-PPA and semantic-PPA cases. Diagnostic utility of [18F]AV-1451was superior to MRI and at least equal to FDG-PET. [18F]AV-1451binding characteristics differ across the PPA variants, and were excellent at distinguishing between the variants. [18F]AV-1451binding characteristics were as good or better than other brain imaging modalities utilized in clinical practice, suggesting that [18F]AV-1451 may have clinical diagnostic utility in PPA.
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DOI：
10.1136/jnnp-2017-316402
发表时间：
2018-10
期刊：
Journal of neurology, neurosurgery, and psychiatry
影响因子：
--
作者：
Bevan-Jones WR;Cope TE;Jones PS;Passamonti L;Hong YT;Fryer TD;Arnold R;Allinson KSJ;Coles JP;Aigbirhio FI;Patterson K;O'Brien JT;Rowe JB
通讯作者：
Rowe JB
影响因子：
7.1
作者：
Lowe VJ;Curran G;Fang P;Liesinger AM;Josephs KA;Parisi JE;Kantarci K;Boeve BF;Pandey MK;Bruinsma T;Knopman DS;Jones DT;Petrucelli L;Cook CN;Graff-Radford NR;Dickson DW;Petersen RC;Jack CR Jr;Murray ME
通讯作者：
Murray ME
影响因子：
16.2
作者：
GOEDERT, M;SPILLANTINI, MG;CROWTHER, RA
通讯作者：
CROWTHER, RA
影响因子：
11
作者：
Bozeat, S;Gregory, CA;Hodges, JR
通讯作者：
Hodges, JR
影响因子：
12.7
作者：
Josephs, Keith A.;Stroh, Alex;Dickson, Dennis W.
通讯作者：
Dickson, Dennis W.