Association between altered systemic inflammatory interleukin-1β and natural killer cell activity and subsequently agitation in patients with Alzheimer disease
Association between altered systemic inflammatory interleukin-1β and natural killer cell activity and subsequently agitation in patients with Alzheimer disease
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DOI：
10.1002/gps.2381
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发表时间：
2010-06-01
影响因子：
4
通讯作者：
Nakamura, H.
中科院分区：
文献类型：
--
作者：
Higuchi, M.;Hatta, K.;Nakamura, H.
目的：阿尔茨海默病（AD）是一种神经退行性疾病，是老年痴呆症的最常见原因，并且经常伴有情绪障碍，包括激动。虽然情绪变化过程中神经内分泌、免疫和炎症功能的证据已经积累，但AD伴发激越的发病机制仍有待阐明。方法：为了阐明神经内分泌、免疫和炎症系统在AD患者激越中的作用，我们检测了激越水平、行为昼夜节律、皮质醇、白细胞介素-1 β（IL-1 β）和自然杀伤细胞活性（NKCA）在对照组无痴呆症和16 AD患者谁被认为是容易激动在他们的养老院。这些行为和血液指标进行了评估，根据16例AD患者（稳定，预激越，激越阶段）的激越阶段的进展情况。结果：在夜间行为和血液皮质醇，IL-1 β和血液NKCA水平降低，在晚上观察到不仅在激越阶段，但也稳定时，在AD患者相比，控制。AD患者激越前期和激越期IL-1 β水平升高，NKCA水平降低，均出现在早晚两个时段。结论：AD患者激越期IL-1 β水平升高，NKCA水平降低，提示炎症导致激越，加重AD。版权所有（C）2009约翰威利父子有限公司
Objective: Alzheimer's disease (AD) is a neurodegenerative disorder that is the most common cause of dementia in the elderly and is frequently accompanied by emotional disorder, including agitation. Although evidence of neuroendocrine immune and inflammatory functions during emotional changes has been accumulated, the pathogenic mechanisms in the development of agitation accompanied by AD remain to be elucidated.Methods: To clarify the involvement of neuroendocrine and immune and inflammatory systems in agitation in AD, we examined agitation levels, circadian rhythms of behavior, cortisol, interleukin-1 beta (IL-1 beta), and natural killer cell activity (NKCA) in controls without dementia and 16 AD patients who were recognized to be easily agitated in their nursing homes. These behavioral and blood indicators were assessed according to the progress of the stage of agitation in 16 AD patients (stable, pre-agitation, and agitation stages).Results: Elevations in night behavior and blood cortisol, IL-1 beta and an reduced blood NKCA level in the evening were observed not only in the agitation stage, but also when stable in AD patients as compared to the control. Increased IL-1 beta and decreased NKCA occurred in both the morning and evening in pre-agitation and agitation stages in AD.Conclusions: The increased IL-1 beta and decreased NKCA with the progress of agitation in AD suggest that inflammation produces agitation and aggravates AD. Copyright (C) 2009 John Wiley & Sons, Ltd.