Early-life sun exposure and risk of melanoma before age 40 years
Early-life sun exposure and risk of melanoma before age 40 years
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DOI：
10.1007/s10552-011-9762-3
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发表时间：
2011-06-01
影响因子：
2.3
通讯作者：
Mann, Graham J.
中科院分区：
文献类型：
--
作者：
Cust, Anne E.;Jenkins, Mark A.;Mann, Graham J.
为了研究早期阳光照射与18 - 39岁之间诊断的侵袭性皮肤黑色素瘤风险之间的关系，分析了来自澳大利亚黑色素瘤家族研究的606例病例和481例对照的数据，该研究是一项基于人群的病例对照家族研究。通过访谈收集自我和父母报告的阳光照射情况。采用非条件logistic回归估计比值比（OR），调整潜在的混杂因素。自我报告的儿童期总日照量与黑色素瘤总体无关，但与18-29岁诊断的黑色素瘤呈正相关（最高与最低四分位数的OR：3.21，95%置信区间（CI）1.38-7.44; P（趋势）0.02;年龄组的P（相互作用）0.09）。分析仅限于自我报告的阳光暴露与其父母回忆的一致的参与者，得出儿童期总阳光暴露的最高与最低三分位数的OR为2.28（95% CI 1.03-5.04; P（趋势）0.05），任何与无严重儿童期晒伤的OR为2.36（95% CI 1.05-5.31）。自我报告的严重晒伤与黑色素瘤的关联仅在倾向于晒黑而不是烧伤的人和几乎没有痣的人中是明显的。
To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years.Data were analysed from 606 cases and 481 controls from the Australian Melanoma Family Study, a population-based, case-control-family study. Self- and parent-reported sun exposure was collected by interview. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for potential confounders.Self-reported childhood total sun exposure was not associated with melanoma overall, but was positively associated with melanoma diagnosed at 18-29 years of age (OR for highest vs. lowest quartile: 3.21, 95% confidence intervals (CI) 1.38-7.44; P (trend) 0.02; P (interaction) by age group 0.09). Analyses restricted to participants whose self-reported sun exposure was concordant with that recalled by their parents gave an OR for the highest versus lowest tertile of childhood total sun exposure of 2.28 (95% CI 1.03-5.04; P (trend) 0.05), and for any versus no severe childhood sunburn of 2.36 (95% CI 1.05-5.31). The association of self-reported severe sunburn with melanoma was evident only in people who tended to tan rather than burn and in people who had few nevi.The association of early-life sun exposure with early-onset melanoma is influenced by host factors.