ROLE OF ADENOSINE IN HETEROSYNAPTIC, POSTTETANIC DEPRESSION IN AREA CA1 OF HIPPOCAMPUS
ROLE OF ADENOSINE IN HETEROSYNAPTIC, POSTTETANIC DEPRESSION IN AREA CA1 OF HIPPOCAMPUS
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DOI：
10.1016/0304-3940(93)90166-i
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发表时间：
1993-05-14
影响因子：
2.5
通讯作者：
TEYLER, TJ
中科院分区：
文献类型：
--
作者：
GROVER, LM;TEYLER, TJ
海马区CA1传入纤维的条件刺激产生由一组独立传入纤维刺激引起的异突触，强直后抑制（PTD）反应。PTD在条件刺激后5秒内出现，相当于兴奋性突触后电位（epsp）减少60-80%，需要3-5分钟的恢复时间。A1腺苷受体拮抗剂可显著降低PTD。在调节刺激过程中释放到细胞外空间或在细胞外空间形成的腺苷可能在片内扩散以抑制诱发的谷氨酸释放。
Conditioning stimulation of afferent fibers in hippocampal area CA1 produced heterosynaptic, posttetanic depression (PTD) of responses evoked by stimulation of an independent set of afferent fibers. PTD was present within 5 s of conditioning stimulation, amounted to a 60-80% reduction of excitatory postsynaptic potentials (EPSPs), and required a period of 3-5 min for recovery. Antagonists of A1 adenosine receptors substantially reduced PTD. Adenosine released into, or formed in, the extracellular space during conditioning stimulation may diffuse within the slice to depress evoked release of glutamate,