Phytoestrogens: food or drug?
Phytoestrogens: food or drug?
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DOI：
10.1201/b14631-25
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发表时间：
2007
期刊：
影响因子：
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通讯作者：
L. Bacciottini;A. Falchetti;B. Pampaloni;E. Bartolini;A. Carossino;M. Brandi
中科院分区：
文献类型：
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作者：
L. Bacciottini;A. Falchetti;B. Pampaloni;E. Bartolini;A. Carossino;M. Brandi
在过去的几年里，饮食和健康之间的关系已经被主流营养学界所接受，并且在这方面，对植物中存在的生物活性化合物的生理作用的兴趣在过去的十年中显著增加。植物雌激素是作为广泛消费的蔬菜的营养成分存在的生物活性分子。它们的名字来源于它们能够结合雌激素受体并在靶组织中诱导雌激素/抗雌激素反应的事实。天然雌激素参与靶组织如子宫、乳腺、垂体和激素反应性肿瘤中的多种程序化事件。植物雌激素存在于许多人类食品中，包括水果（李子、梨、苹果葡萄浆果等）、蔬菜（豆类、豆芽、卷心菜、菠菜、大豆、谷物、啤酒花、大蒜、洋葱等）、葡萄酒、茶，并且它们已在许多植物膳食补充剂中被鉴定。它们包括各种各样的结构不同的化合物，如主要在大豆中发现的异黄酮，在谷物中发现的木脂素，在葡萄皮中发现的芪。其他研究较少的化合物包括黄酮、黄烷、异黄烷和香豆烷。任何化合物的雌激素或抗雌激素活性都取决于化合物与雌激素受体（ERα，ERβ）相互作用的能力，本文从药理学角度对植物雌激素的雌激素或抗雌激素活性进行了综述。
Within the past several years, the relation between diet and health has been accepted by the mainstream nutrition community and in this connection interest in the physiological role of bioactive compounds present in plants has dramatically increased over the last decade.The phytoestrogens are bioactive molecules present as nutritional constituents of widely consumed vegetables. Their name derives from the fact that they are able to bind to estrogen receptors and to induce an estrogenic/antiestrogenic response in target tissues. Natural estrogens are involved in a multiplicity of programmed events in target tissues as uterus, breast, pituitary gland and hormone responsive tumors. Phytoestrogens are present in many human foodstuffs including fruits (plum, pear, apple grape berries, …), vegetables (beans, sprouts, cabbage, spinach, soybeans, grains, hops, garlic, onion,…), wine, tea, and they have been identified in a number of botanical dietary supplements. They include a wide variety of structurally different compounds such as isoflavones, mainly found in soy, lignans found in grains, stilbenes found in the skin of grapes. Other less investigated compounds include flavones, flavans, isoflavanes and coumestans. The estrogenic or antiestrogenic activity of any chemicals depends on the ability of the compound to interact with the ERs (ERα , ERβ ).This article reported the knowledge about the activity of phytoestrogens from a pharmacological point of view for their estrogenicity or antiestrogenicity.