Metabolic clearance rates of the subunits of human chorionic gonadotropin in man.
Metabolic clearance rates of the subunits of human chorionic gonadotropin in man.
复制标题
人绒毛膜促性腺激素亚基的代谢清除率。
DOI：
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发表时间：
1979
影响因子：
5.8
通讯作者：
B. C. Nisula
中科院分区：
文献类型：
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作者：
R. E. Wehmann;B. C. Nisula
在正常受试者中静脉注射高度纯化的hCG α和β亚基（hCG α和hCG β）制剂。快速注射后，两个亚基从血清中的消失是非线性的绘制在半对数图。拟合每例受试者的双组分指数曲线，并使用曲线参数估计每个亚基的MCR、表观初始分布容积（Vd）和快速相和缓慢相消失的半衰期。hCG β的Vd与hCG α的Vd无法区分（分别为1958 +/- 131 vs. 1729 +/- 99 ml/m2）。hCG β的快相半衰期显著长于hCG α（41.2 +/- 1.7 vs. 13.0 +/- 0.9 min; P <0.001），hCG β的慢相半衰期也显著长于hCG α（236 +/- 41 vs. 76 +/- 19 min; P <0.01）。hCG α的估计MCR为49.7 +/- 1.6 ml/min.m2;该值显著大于hCG β（19.0 +/- 0.7 ml/min.m2; P <0.001）。性别之间没有显着差异的亚基确定的参数进行了观察。以2.7微克/分钟的速率连续输注亚单位可使hCG β的稳态血液水平显著高于hCG α（59.1 ± 7.8 vs 24.4 ± 0.7 ng/ml; P小于0.02），hCG α的MCR是hCG β MCR的3倍（72.2 +/- 4.9 vs. 21.6 +/- 2.8 ml/min.m2; P小于0.001）。我们得出结论，hCG亚基具有相似的Vds，但由于hCG α在快速和缓慢阶段的消失半衰期要短得多，因此hCG α的MCR远大于hCG β。
Highly purified preparations of the alpha- and beta-subunits of hCG (hCG alpha and hCG beta) were injected iv in normal subjects. After rapid injection, the disappearance of both subunits from serum was nonlinear when plotted on a semilog graph. A two-component exponential curve was fitted for each subject, and the curve parameters were used to estimate the MCR, apparent initial volume of distribution (Vd), and half-times of disappearance of the rapid and slow phase for each subunit. The Vd of hCG beta was indistinguishable from that of hCG alpha (1958 +/- 131 vs. 1729 +/- 99 ml/m2, respectively). The rapid phase half-time for hCG beta was significantly longer than that of hCG alpha (41.2 +/- 1.7 vs. 13.0 +/- 0.9 min; P less than 0.001), and the slow phase half-time of hCG beta was also significantly longer than that of hCG alpha (236 +/- 41 vs. 76 +/- 19 min; P less than 0.01). The estimated MCR of hCG alpha was 49.7 +/- 1.6 ml/min.m2; this value was significantly greater than that of hCG beta (19.0 +/- 0.7 ml/min.m2; P less than 0.001). No significant differences between sexes in parameters determined for the subunits were observed. Continuous infusion of subunits at a rate of 2.7 microgram/min achieved a steady state blood level of hCG beta that was significantly greater than that of hCG alpha (59.1 +/- 7.8 vs. 24.4 +/- 0.7 ng/ml; P less than 0.02) and gave a MCR of hCG alpha that was 3 times greater than the MCR of hCG beta (72.2 +/- 4.9 vs. 21.6 +/- 2.8 ml/min.m2; P less than 0.001). We conclude that the hCG subunits have similar Vds, but since hCG alpha has much shorter half-times of disappearance in both rapid and slow phases, the MCR of hCG alpha is much greater than that of hCG beta.