The PTPN22 C1858T functional polymorphism and autoimmune diseases - a meta-analysis
The PTPN22 C1858T functional polymorphism and autoimmune diseases - a meta-analysis
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DOI：
10.1093/rheumatology/kel170
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发表时间：
2007-01-01
期刊：
影响因子：
5.5
通讯作者：
Harley, J. B.
中科院分区：
文献类型：
--
作者：
Lee, Y. H.;Rho, Y. H.;Harley, J. B.
客观的。评估综合证据是否显示蛋白酪氨酸磷酸酶非受体22（PTPN22）C1858T多态性与自身免疫性疾病之间的关联，并总结多态性与自身免疫性疾病易感性相关的效应大小。方法。我们通过综合 Medline 搜索和参考文献综述调查了 PTPN22 C1858T 多态性和自身免疫性疾病的研究。在随机效应模型中对基因型 T/T（隐性效应）、T/T + C/T（显性效应）和 T 等位基因进行荟萃分析。结果。共有 29 项研究进行了 43 项比较，其中包括 13 项类风湿性关节炎 (RA)、6 项系统性红斑狼疮 (SLE)、6 项 1 型糖尿病 (T1D)、3 项格雷夫氏病 (GD)、4 项炎症性肠病 (IBD)、3 项幼年特发性关节炎 (JIA)、2 项银屑病、2 项多发性硬化症、2 项艾迪生氏病和 2 项乳糜泻 用于荟萃分析。 RA、SLE、GD 和 T1D 中 T 等位基因、T/T 和 T/T + C/T 基因型的总体比值比 (ORS) 显着增加（T 等位基因的 OR 分别 = 1.58、1.49、1.85、1.61，P < 0.00001）。这项荟萃分析显示了 T 等位基因和 T/T 基因型与 JIA 之间的关联（OR = 1.34，P = 0.03；OR = 1.97，P = 0.02），但没有揭示 PTPN22 C1858T 多态性与 IBD、银屑病、多发性硬化症、阿狄森氏病和乳糜泻之间的关联。结论。这项荟萃分析表明，PTPN22 1858T 等位基因赋予 RA、SLE、GD、T1D 和 JIA 易感性，支持 PTPN22 基因与自身免疫性疾病亚组相关的证据。
Objective. To assess whether combined evidence shows the association between the protein tyrosine phosphatase non-receptor 22 (PTPN22) C1858T polymorphism and autoimmune diseases, and to summarize the effect size of the polymorphism associated with susceptibility of autoimmune diseases.Methods. We surveyed studies on the PTPN22 C1858T polymorphism and autoimmune diseases using comprehensive Medline search and review of the references. Meta-analysis was performed for genotypes T/T (recessive effect), T/T + C/T (dominant effect) and T-allele in random effects models.Results. Twenty-nine studies with 43 comparisons including 13 rheumatoid arthritis (RA), six systemic lupus erythematosus (SLE), six type-1 DM (T1D), three Grave's disease (GD), four inflammatory bowel diseases (IBD), three juvenile idiopathic arthritis (JIA), two psoriasis, two multiple sclerosis, two Addison's disease and two Celiac disease were available for the meta-analysis. The overall odds ratios (ORS) for T-allele, T/T and T/T + C/T genotypes were significantly increased in RA, SLE, GD and T1D (OR for T-allele = 1.58, 1.49, 1.85, 1.61, respectively, P < 0.00001). This meta-analysis showed the association between the T-allele and the T/T genotype and JIA (OR = 1.34, P = 0.03; OR = 1.97, P = 0.02) but did not reveal the association between the PTPN22 C1858T polymorphism and IBD, psoriasis, multiple sclerosis, Addison's disease and Celiac disease.Conclusion. This meta-analysis demonstrates that the PTPN22 1858T allele confers susceptibility to RA, SLE, GD, T1D and JIA, supporting evidence of association of the PTPN22 gene with subgroup of autoimmune diseases.