Rheology of nanostructured lipid carriers (NLC) suspended in a viscoelastic medium.
Rheology of nanostructured lipid carriers (NLC) suspended in a viscoelastic medium.
复制标题
悬浮在粘弹性介质中的纳米结构脂质载体 (NLC) 的流变学。
DOI：
--
复制
发表时间：
2005
期刊：
影响因子：
--
通讯作者：
R. Müller
中科院分区：
文献类型：
--
作者：
E. Souto;S. Gohla;R. Müller
使用两种不同的纳米脂质载体(NLC)配方对胶体脂质纳米颗粒分散体进行了流变学测量，这些配方用于葵花籽油和α-生育酚等物质的美容应用。这项研究表明，尽管颗粒大小相似甚至相同，但NLC水分散液的流变性和粘弹性性质因油相组成和储存温度的不同而有很大的不同。NLC中活性成分的负载量为颗粒质量的30%。以硬脂醇为脂质基质，用光子相关光谱仪测定其粒径为210~270 nm。总的来说，葵花油负载的NLC分散体具有较高的储能模数(G‘)、损耗模数(G“)和复粘度(ETA*)。低温(4℃和20℃)储存不仅延缓了微结构的建立，而且还受到制备后所载成分和储存历史的影响，即室温储存加速了最终悬浮结构的建立。
Colloidal lipid nanoparticle dispersions have been characterized by rheological measurements using two different nanostructured lipid carrier (NLC)-based formulations intended for cosmetic application of substances like sunflower oil and alpha-tocopherol. This study has shown that rheological and viscoelastic properties of aqueous NLC dispersions are quantitatively very different depending on the composition of the oil phase and the temperature of storage despite similar or even identical particle size. NLC were loaded with 30% active ingredient relative to the particle mass. Stearyl alcohol was used as lipid matrix and the particle sizes determined by photon correlation spectroscopy were in the range 210-270 nm. In general, sun flower oil-loaded NLC dispersions showed distinctly higher storage modulus (G'), loss modulus (G") and complex viscosity (eta*). Storage at lower temperature (4 degrees C versus 20 degrees C) delay the build up of a microstructure affected not only by size and stabilizer but also loaded ingredient and storage history after preparation, i.e. storage at room temperature accelerates the build up of a final suspension structure.