Androgen implants in medial amygdala briefly maintain noncontact erection in castrated male rats
Androgen implants in medial amygdala briefly maintain noncontact erection in castrated male rats
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DOI：
10.1006/hbeh.2002.1821
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发表时间：
2002-11-01
影响因子：
3.5
通讯作者：
Sachs, BD
中科院分区：
文献类型：
--
作者：
Bialy, M;Sachs, BD
去势雄性大鼠会导致它们对难以接近的发情雌性大鼠的正常勃起反应迅速丧失。以前的研究已经证明，这些非接触性勃起(NCEs)是性唤醒的假定迹象，可以通过全身用睾酮(T)或双氢睾酮(DHT)恢复，但不能用雌二醇(E)。我们研究了将雄激素注射到去势大鼠的杏仁内侧核(Mea)是否会维持NCE。在实验1中，男性接受针对Mea的双侧导管填充T、DHT或E。对照组男性被植入相同的荷尔蒙填充的皮下插管和MEA中的空白插管，或者他们在前脑接受T。在手术后的2周内，对雄性进行了两次NCE和交配测试。大约一半的男性男性在去势后一周出现NCEs，但一周后几乎没有反应。雄激素植入物越靠近后背中动脉(MeApd)，NCE潜伏期越短。皮下注射雄激素的男性在这两项测试中都没有NCEs，前脑植入的男性也很少。一些接受MEA或皮下注射E的男性在每次测试中都有NCE。在交配试验中，类固醇治疗的类型不影响射精的发生率或大多数交配措施，而插管与MeApd的接近程度仅预测射精后间隔期间从射精到NCE发生的时间。实验2表明，MEA中含有雄激素的雄性所显示的NCEs是对发情雌性的反应，而不是自发的。结果表明，雄激素可能被雌激素增强，作用于背后中脑，以促进NCE及其相关的觉醒。(C)2002年埃尔塞维尔科学公司(美国)。
Castration of male rats causes a rapid loss of their normal erectile response to inaccessible estrous females. Previous studies had demonstrated that these noncontact erections (NCEs), a putative sign of sexual arousal, could be restored by systemic treatment with testosterone (T) or dihydrotestosterone (DHT), but not estradiol (E). We examined whether androgen delivered to the medial amygdala (MeA) of castrated rats would maintain NCE. In Experiment 1, males received bilateral cannulae filled with T, DHT, or E directed at the MeA. Control males had the same hormone-filled cannulae implanted subcutaneously and blank cannulae in the MeA, or they received T in the anterior forebrain. During the 2 weeks after surgery, males were tested twice for NCE and copulation. About half the males with androgens in the MeA had NCEs 1 week after castration, but few responded a week later. Closer proximity of androgen implants to the posterodorsal MeA (MeApd) predicted shorter NCE latencies. No males with subcutaneous androgen had NCEs in either test, and few anterior forebrain-implanted males did. Some males receiving E in MeA or subcutaneously had NCE in each test. In copulation tests, the type of steroid treatment did not affect the incidence of ejaculation or most measures of copulation, and the proximity of cannulae to MeApd predicted only the time from ejaculation to the occurrence of NCE during the postejaculatory interval. Experiment 2 showed that NCEs displayed by males with androgen in MeA occurred in response to estrous females, not spontaneously. The results suggest that androgens, perhaps augmented by estrogen, act in the posterodorsal MeA to facilitate NCE and its associated arousal. (C) 2002 Elsevier Science (USA).