Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion.
Comparison of single injection and three monthly injections of intravitreal bevacizumab for macular edema associated with branch retinal vein occlusion.
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DOI：
10.2147/opth.s76261
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Ohji M
中科院分区：
文献类型：
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作者：
Ito Y;Saishin Y;Sawada O;Kakinoki M;Miyake T;Sawada T;Kawamura H;Ohji M
我们的目的是比较玻璃体内注射贝伐单抗 (IVB) 在两组前瞻性、连续的视网膜分支静脉阻塞 (BRVO) 后黄斑水肿 (ME) 患者中的 1 年疗效和安全性结果。 BRVO 后 25 只眼出现 ME，接受 1 次 IVB 注射（单次注射组），27 只眼接受 3 个月 IVB 注射（3 次注射组）。两组患者每月进行一次随访，为期 12 个月。治疗前后评估光学相干断层扫描的最佳矫正视力（BCVA）和中央凹厚度（CFT）。如果与上次就诊时测量的值相比，平均 CFT 增加 100 μm 或更多，或者 BCVA 减少最小分辨率角度 (logMAR) 单位的对数 0.1 或更多，则患者有资格接受 IVB 注射。单次注射组的平均 logMAR BCVA 和 CFT 分别从 0.56 提高到 0.33，从 598 μm 提高到 348 μm（P<0.001），三次注射组从 0.55 提高到 0.26，从 514 μm 提高到 293 μm（P<0.001）。研究期间，单次注射组的平均注射总数显着少于三次注射组（分别为2.1和4.3，P<0.001）。两组均未出现与 IVB 注射相关的严重并发症。与三次注射组相比，单次注射组以更少的注射次数实现了继发于 BRVO 的 ME 相似的视觉效果。
Our aim was to compare the 1 year efficacy and safety results of intravitreal bevacizumab (IVB) in two prospective, consecutive groups of patients with macular edema (ME) following branch retinal vein occlusion (BRVO). Twenty-five eyes with ME after BRVO received one IVB injection (single-injection group) and 27 eyes received three monthly IVB injections (three-injection group). Both groups were followed monthly for 12 months. The best-corrected visual acuity (BCVA) and the central foveal thickness (CFT) on optical coherence tomography were evaluated before and after treatment. Patients were eligible to receive an IVB injection if the mean CFT increased 100 μm or more or the BCVA decreased 0.1 logarithm of the minimum angle of resolution (logMAR) unit or more compared with values measured on the last visit. The mean logMAR BCVA and CFT, respectively, improved from 0.56 to 0.33 and from 598 μm to 348 μm in the single-injection group (P<0.001) and from 0.55 to 0.26 and from 514 μm to 293 μm in the three-injection group (P<0.001). During the study period, the mean total number of injections was significantly smaller in the single-injection group than in the three-injection group (2.1 and 4.3, respectively, P<0.001). No serious complications related to the IVB injections developed in either group. The single-injection group achieved similar visual outcomes for ME secondary to BRVO with fewer injections compared with the three-injection group.