Significance of hydrogen sulfide production in the pancreatic β-cell.
Significance of hydrogen sulfide production in the pancreatic β-cell.
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DOI：
10.1254/jphs.11r01cp
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发表时间：
2011
影响因子：
3.5
通讯作者：
S. Taniguchi;I. Niki
中科院分区：
文献类型：
--
作者：
S. Taniguchi;I. Niki
Hydrogen sulfide (H(2)S) is an important signaling molecule in various mammalian cells and tissues. H(2)S is synthesized from L-cysteine and regulates several cellular and physiological phenomena (vasorelaxation, hormone secretion, and apoptosis) and multicellular events (neuromodulation and inflammatory responses). H(2)S can be produced in pancreatic β-cells by cystathionine β-synthase (CBS) or cystathionine γ-lyase (CSE). H(2)S inhibits insulin release and regulates β-cell survival. We found that glucose stimulation increased CSE expression at transcript and protein levels in mouse pancreatic islets. We also found that H(2)S protects β-cells that were chronically exposed to high glucose from apoptotic cell death. Loss of β-cell mass and failures of β-cell function are important in the pathogenesis and/or progression of diabetes mellitus; therefore, molecular analyses of the mechanisms of H(2)S production and its protective effects on β-cells may lead to new insights into diabetes mellitus.
